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Construction and evaluation of tumor nucleus-targeting nanocomposite for cancer dual-mode imaging – Guiding photodynamic therapy/photothermal therapy

Zhou, Jie ; Wang, Qiaolei ; Geng, Shizhen ; Lou, Rui ; Yin, Qianwen ; Ye, Weiran

Materials Science & Engineering C, 2019-09, Vol.102, p.541-551

Netherlands: Elsevier B.V

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Título:
Construction and evaluation of tumor nucleus-targeting nanocomposite for cancer dual-mode imaging – Guiding photodynamic therapy/photothermal therapy
Autor: Zhou, Jie ; Wang, Qiaolei ; Geng, Shizhen ; Lou, Rui ; Yin, Qianwen ; Ye, Weiran
Assuntos: Au25 nanoclusters ; Blood flow ; Captopril ; Cell viability ; Computed tomography ; Deoxyribonucleic acid ; Dexamethasone ; Diagnostic systems ; DNA ; DNA damage ; Electrostatic properties ; Glucocorticoids ; Heat ; I.R. radiation ; Infrared lasers ; Irradiation ; Nanocomposites ; Nanoparticles ; Nuclei (cytology) ; Nucleus targeting ; Photodynamic therapy ; Photosensitivity ; PTT/PDT ; Single excitation laser ; Tumors ; WS2 nanoparticles
É parte de: Materials Science & Engineering C, 2019-09, Vol.102, p.541-551
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: To tackle the barrier of the insufficient intra-cellular delivery of reactive oxygen species (ROS) and heat, we designed a multifunctional nanoplatform to release ROS and heat directly in the cell nucleus for enhancing combined photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors. As a photothermal agent, WS2 nanoparticles were adsorbed photosensitive Au25(Captopril)18− (Au25) nanoclusters via electrostatic interaction. And Dexamethasone (Dex), a glucocorticoid with nucleus targeting capability, played a key role in the intra-nuclear process of heat and ROS. PTT can increase intra-tumoral blood flow to promote Au25 produce more ROS for PDT. Under near infrared (NIR) laser irradiation at a single 808 nm, these nucleus targeting WS2 nanoplatforms showed a significant decreased cell viability of 18.2 ± 1.7% and a high DNA damage degree of 59.6 ± 8.3%. Furthermore, the WS2 nanoplatform could be further used for X-ray computed tomography (CT) images. Taken together, our study provided a new prospect for effectively diagnostic and enhancing PTT/PDT efficacy. [Display omitted] •Developed a PDT/PTT nanoplatform to directly release ROS and heat in the cell nucleus•A significant decreased cell viability and a high DNA damage degree at a single excitation laser (at 808 nm without 660 nm)•A new prospect for effectively diagnostic and enhancing PTT/PDT efficacy
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Construction and evaluation of tumor nucleus-targeting nanocomposite for cancer dual-mode imaging – Guiding photodynamic therapy/photothermal therapy

Zhou, Jie ; Wang, Qiaolei ; Geng, Shizhen ; Lou, Rui ; Yin, Qianwen ; Ye, Weiran

Netherlands: Elsevier B.V

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