Idioma:

Association study between candidate genes involved in cell-cell adhesion and non-syndromic cleft lip with or without cleft palate in Chinese population

Yuan, Y ; Wang, P ; Wu-Chou, Y H ; Ye, X Q ; Huang, S Z ; Shi, B ; Wang, K ; Wang, Z Q ; Liu, D J ; Wang, Z F ; Wu, T ; Wang, H

Beijing da xue xue bao. Journal of Peking University. Yi xue ban, 2016-06, Vol.48 (3), p.403-408 [Periódico revisado por pares]

China

Texto completo disponível

Citações Citado por

Enviar para

Título:
Association study between candidate genes involved in cell-cell adhesion and non-syndromic cleft lip with or without cleft palate in Chinese population
Autor: Yuan, Y ; Wang, P ; Wu-Chou, Y H ; Ye, X Q ; Huang, S Z ; Shi, B ; Wang, K ; Wang, Z Q ; Liu, D J ; Wang, Z F ; Wu, T ; Wang, H
Assuntos: Asian Continental Ancestry Group - genetics ; Cell Adhesion - genetics ; Child ; Cleft Lip - genetics ; Cleft Palate - genetics ; Female ; Gene-Environment Interaction ; Genetic Linkage ; Genome-Wide Association Study ; Humans ; Logistic Models ; Maternal Exposure ; Polymorphism, Single Nucleotide ; Pregnancy
É parte de: Beijing da xue xue bao. Journal of Peking University. Yi xue ban, 2016-06, Vol.48 (3), p.403-408
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: To explore the association and gene-environment interaction between single nucleotide polymorphisms (SNPs) involved in cell-cell adhesion and non-syndromic cleft lip with or without cleft palate (NSCL/P) among Chinese population. A total of 806 NSCL/P trios were drawn by an international consortium, which conducted a genome-wide association study (GWAS) using a case-parent trio design to investigate genes affecting risks to NSCL/P. The transmission disequilibrium test (TDT) was used to explore the association between cell-cell adhesion genes, including CDH1, CTNNB1, PVRL1, PVRL2, PVRL3, ACTN1, VCL, LEF1, and NSCL/P. Conditional Logistic regression models were used to estimate effects on risk of exposed and unexposed children. Four common maternal exposures including maternal smoking, environmental tobacco smoke, alcohol consumption and multivitamin supplementation during pregnancy were included in this study. A total of 226 SNP markers were tested after quality control in this study. Although 23 SNPs in three
Editor: China
Idioma: Chinês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Association study between candidate genes involved in cell-cell adhesion and non-syndromic cleft lip with or without cleft palate in Chinese population

Yuan, Y ; Wang, P ; Wu-Chou, Y H ; Ye, X Q ; Huang, S Z ; Shi, B ; Wang, K ; Wang, Z Q ; Liu, D J ; Wang, Z F ; Wu, T ; Wang, H

China

Buscando em bases de dados remotas. Favor aguardar.