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Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages

Barberá‐Cremades, Maria ; Baroja‐Mazo, Alberto ; Pelegrín, Pablo

Journal of leukocyte biology, 2016-02, Vol.99 (2), p.289-299 [Periódico revisado por pares]

United States

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Título:
Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages
Autor: Barberá‐Cremades, Maria ; Baroja‐Mazo, Alberto ; Pelegrín, Pablo
Assuntos: Adenine - pharmacology ; Adenine Nucleotides - pharmacology ; adenosine ; adenosine receptors ; Animals ; beta-N-Acetylhexosaminidases - biosynthesis ; beta-N-Acetylhexosaminidases - genetics ; beta-N-Acetylhexosaminidases - pharmacology ; Cell Cycle - drug effects ; Cell Division - drug effects ; Cells, Cultured ; extracellular ATP ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - immunology ; Inflammation - immunology ; Inflammation - pathology ; Interferon-gamma - pharmacology ; Interleukin-4 - pharmacology ; Lectins - biosynthesis ; Lectins - genetics ; Lectins - pharmacology ; Lipopolysaccharides - pharmacology ; Macrophage Activation - drug effects ; Macrophages - classification ; Macrophages - cytology ; Macrophages - drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myelopoiesis - drug effects ; Phenotype ; Purinergic P1 Receptor Agonists - pharmacology ; Purinergic P2 Receptor Agonists - pharmacology ; Purinergic P2 Receptor Antagonists - pharmacology ; purinergic receptors ; Receptors, Purinergic P1 - physiology ; Receptors, Purinergic P2 - physiology ; Receptors, Purinergic P2X7 - biosynthesis ; Receptors, Purinergic P2X7 - deficiency ; Receptors, Purinergic P2X7 - drug effects ; Receptors, Purinergic P2X7 - genetics ; Recombinant Proteins - pharmacology ; Signal Transduction - drug effects ; Specific Pathogen-Free Organisms ; Ym1
É parte de: Journal of leukocyte biology, 2016-02, Vol.99 (2), p.289-299
Notas: These authors contributed equally to this work.
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Descrição: Purinergic signaling controls macrophage differentiation resulting in inhibition of growth and M2 macrophage phenotype. Macrophages represent a highly heterogenic cell population of the innate immune system, with important roles in the initiation and resolution of the inflammatory response. Purinergic signaling regulates both M1 and M2 macrophage function at different levels by controlling the secretion of cytokines, phagocytosis, and the production of reactive oxygen species. We found that extracellular nucleotides arrest macrophage differentiation from bone marrow precursors via adenosine and P2 receptors. This results in a mature macrophage with increased expression of M2, but not M1, genes. Similar to adenosine and ATP, macrophage growth arrested with LPS treatment resulted in an increase of the M2‐related marker Ym1. Recombinant Ym1 was able to affect macrophage proliferation and could, potentially, be involved in the arrest of macrophage growth during hematopoiesis.
Editor: United States
Idioma: Inglês

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Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages

Barberá‐Cremades, Maria ; Baroja‐Mazo, Alberto ; Pelegrín, Pablo

United States

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