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Association study between candidate genes on transforming growth factor-β signaling pathway and the risk of non-syndromic cleft lip with or without cleft palate in Chinese populations

Wang, Zhu-qing ; Wang, Ping ; Wu-Chou, Yah-huei ; Ye, Xiao-qian ; Huang, Shang-zhi ; Shi, Bing ; Wang, Ke ; Yuan, Yuan ; Liu, Dong-jing ; Wu, Tao ; Wang, Hong ; Beaty, Terri H

Beijing da xue xue bao. Journal of Peking University. Yi xue ban, 2015-06, Vol.47 (3), p.384-389 [Periódico revisado por pares]

China

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Título:
Association study between candidate genes on transforming growth factor-β signaling pathway and the risk of non-syndromic cleft lip with or without cleft palate in Chinese populations
Autor: Wang, Zhu-qing ; Wang, Ping ; Wu-Chou, Yah-huei ; Ye, Xiao-qian ; Huang, Shang-zhi ; Shi, Bing ; Wang, Ke ; Yuan, Yuan ; Liu, Dong-jing ; Wu, Tao ; Wang, Hong ; Beaty, Terri H
Assuntos: Asian Continental Ancestry Group - genetics ; Cleft Lip - genetics ; Cleft Palate - genetics ; Gene-Environment Interaction ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide ; Signal Transduction ; Transforming Growth Factors - genetics
É parte de: Beijing da xue xue bao. Journal of Peking University. Yi xue ban, 2015-06, Vol.47 (3), p.384-389
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: To explore the association between 10 candidate genes on transforming growth factor-β (TGFB) signaling pathway and non-syndromic cleft lip with or without cleft palate (NSCL/P) among Chinese populations, and to study the gene-environment interaction. A total of 806 Chinese Han NSCL/P trios were ascertained from an international consortium, which conducted a genome-wide association study using a case-parent trio design to investigate the genes affecting risk to NSCL/P. The transmission disequilibrium test (TDT) was used to test for effects of 343 single nucleotide polymorphisms (SNPs) in 10 genes on TGFB signaling pathway including DCN, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, BAMBI, SMAD2, SMAD3 and SMAD4. The conditional regression models were used to test for gene-environment interaction. For TDT, although 19 SNPs showed nominal significant association with NSCL/P, no significant evidence of association was seen for all SNPs in 806 NSCL/P trios after Bonferroni correction. The interactions between genes and mat
Editor: China
Idioma: Chinês

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Association study between candidate genes on transforming growth factor-β signaling pathway and the risk of non-syndromic cleft lip with or without cleft palate in Chinese populations

Wang, Zhu-qing ; Wang, Ping ; Wu-Chou, Yah-huei ; Ye, Xiao-qian ; Huang, Shang-zhi ; Shi, Bing ; Wang, Ke ; Yuan, Yuan ; Liu, Dong-jing ; Wu, Tao ; Wang, Hong ; Beaty, Terri H

China

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