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Electrospinning collagen/chitosan/poly(L-lactic acid-co-ϵ-caprolactone) to form a vascular graft: Mechanical and biological characterization

Yin, Anlin ; Zhang, Kuihua ; McClure, Michael J. ; Huang, Chen ; Wu, Jinglei ; Fang, Jun ; Mo, Xiumei ; Bowlin, Gary L. ; Al-Deyab, Salem S. ; El-Newehy, Mohamed

Journal of biomedical materials research. Part A, 2013-05, Vol.101A (5), p.1292-1301 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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Título:
Electrospinning collagen/chitosan/poly(L-lactic acid-co-ϵ-caprolactone) to form a vascular graft: Mechanical and biological characterization
Autor: Yin, Anlin ; Zhang, Kuihua ; McClure, Michael J. ; Huang, Chen ; Wu, Jinglei ; Fang, Jun ; Mo, Xiumei ; Bowlin, Gary L. ; Al-Deyab, Salem S. ; El-Newehy, Mohamed
Assuntos: Animals ; biocompatibility ; Biocompatible Materials - chemistry ; Biological and medical sciences ; Blended ; Blood Vessel Prosthesis ; Bursting strength ; Cell Line ; Cell Proliferation ; Chitosan ; Chitosan - chemistry ; Collagen - chemistry ; collagen/chitosan/P(LLA-CL) blend ; Collagens ; Elastic Modulus ; Electrospinning ; Endothelial cells ; Endothelial Cells - cytology ; Grafting ; Materials Testing ; mechanical properties ; Medical sciences ; Polyesters - chemistry ; Polylactic acid ; Porosity ; Scaffolds ; Stress, Mechanical ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Swine ; Technology. Biomaterials. Equipments ; Tensile Strength ; vascular graft ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels
É parte de: Journal of biomedical materials research. Part A, 2013-05, Vol.101A (5), p.1292-1301
Notas: Doctorial Innovation Fund of Donghua University - No. BC201127
ark:/67375/WNG-XSWNFK6B-Q
istex:85416877F2B5FD8541BA9B51B30374E9404AC609
The National Plan for Science and Technology - No. 10-NAN1013-02
Science and Technology Commission of Shanghai Municipality Program - No. 11nm0506200
National High Technology Research and Development Program - No. 2008AA03Z305
National Nature Science Foundation of China - No. 31070871
ArticleID:JBM34434
How to cite this article: Yin A, Zhang K, McClure MJ, Huang C, Wu J, Fang J, Mo X, Bowlin GL, Al-Deyab SS, El-Newehy M. 2013. Electrospinning collagen/chitosan/poly(L-lactic acid-co-ϵ-caprolactone) to form a vascular graft: Mechanical and biological characterization. J Biomed Mater Res Part A 2013:101A:1292-1301.
lactic acid
ϵ‐caprolactone) to form a vascular graft: Mechanical and biological characterization. J Biomed Mater Res Part A 2013:101A:1292–1301.
Yin A, Zhang K, McClure MJ, Huang C, Wu J, Fang J, Mo X, Bowlin GL, Al‐Deyab SS, El‐Newehy M. 2013. Electrospinning collagen/chitosan/poly
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Descrição: For blood vessel tissue engineering, an ideal vascular graft should possess excellent biocompatibility and mechanical properties. For this study, a elastic material of poly (L‐lactic acid‐co‐ϵ‐caprolactone) (P(LLA‐CL)), collagen and chitosan blended scaffold at different ratios were fabricated by electrospinning. Upon fabrication, the scaffolds were evaluated to determine the tensile strength, burst pressure, and dynamic compliance. In addition, the contact angle and endothelial cell proliferation on the scaffolds were evaluated to demonstrate the structures potential to serve as a vascular prosthetic capable of in situ regeneration. The collagen/chitosan/P(LLA‐CL) scaffold with the ratio of 20:5:75 reached the highest tensile strength with the value of 16.9 MPa, and it was elastic with strain at break values of ∼112%, elastic modulus of 10.3 MPa. The burst pressure strength of the scaffold was greater than 3365 mmHg and compliance value was 0.7%/100 mmHg. Endothelial cells proliferation was significantly increased on the blended scaffolds versus the P(LLA‐CL). Meanwhile, the endothelial cells were more adherent based on the increase in the degree of cell spreading on the surface of collagen/chitosan/P(LLA‐CL) scaffolds. Such blended scaffold especially with the ratio of 20:5:75 thus has the potential for vascular graft applications. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Electrospinning collagen/chitosan/poly(L-lactic acid-co-ϵ-caprolactone) to form a vascular graft: Mechanical and biological characterization

Yin, Anlin ; Zhang, Kuihua ; McClure, Michael J. ; Huang, Chen ; Wu, Jinglei ; Fang, Jun ; Mo, Xiumei ; Bowlin, Gary L. ; Al-Deyab, Salem S. ; El-Newehy, Mohamed

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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