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Association of genetic variants in TOMM7 gene and gene environment interaction with type 2 diabetes in Chinese Dong population

Liu, Liya ; Chen, Lizhang ; Li, Zhanzhan ; Li, Liang ; Wang, Mian ; Qu, Jian ; Xue, Jing

Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2015-01, Vol.40 (1), p.31-38

China

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Título:
Association of genetic variants in TOMM7 gene and gene environment interaction with type 2 diabetes in Chinese Dong population
Autor: Liu, Liya ; Chen, Lizhang ; Li, Zhanzhan ; Li, Liang ; Wang, Mian ; Qu, Jian ; Xue, Jing
Assuntos: Alleles ; Asian Continental Ancestry Group - genetics ; Case-Control Studies ; China ; Diabetes Mellitus, Type 2 - genetics ; Gene-Environment Interaction ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Humans ; Membrane Proteins - genetics ; Mitochondrial Proteins - genetics ; Polymorphism, Genetic
É parte de: Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2015-01, Vol.40 (1), p.31-38
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: To investigate the association of 7 novel genetic loci identified in a recent genome-wide association studies (GWAS) with T2DM in Chinese Dong populations. A case-controlled study was performed in individuals of Chinese Dong nationality. The genotypes of PARD3B (rs849230), LOC729993 (rs149228), EPHA4 (rs16862811), HNT (rs3099797), PTPRD (rs17584499 and rs649891), TOMM7 (rs2240727) genes were determined by Multiplex PCR-SNaPshot. The independent association between each polymorphism and T2DM was assessed by unconditional binary logistic regression analysis. The gene-environment interaction was assessed by marginal structural linear odds model. A total of 209 cases of T2DM and 209 control subjects were enrolled in the study. The polymorphism of rs2240727 in TOMM7 gene was associated with T2DM (OR=1.50, per copy of the risk T allele, P=0.004). In addition, CT (OR=2.07, 95% CI: 1.14-3.76) and TT (OR=2.75, 95% CI: 1.46-5.17) were risk genotypes for T2DM. After the correction for multiple test, the association rema
Editor: China
Idioma: Chinês

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Association of genetic variants in TOMM7 gene and gene environment interaction with type 2 diabetes in Chinese Dong population

Liu, Liya ; Chen, Lizhang ; Li, Zhanzhan ; Li, Liang ; Wang, Mian ; Qu, Jian ; Xue, Jing

China

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