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Decreases in cholesterol in HIV-seronegative men using emtricitabine/tenofovir pre-exposure prophylaxis: lipid results of iPrEx

Mulligan, K ; Glidden, D V ; Anderson, P L ; McMahan, V ; Guanira, J V ; Lama, J R ; Buchbinder, S P ; Chariyalertsak, S ; Bekker, L-G ; Schechter, M ; Veloso, V G ; Wang, F ; Grant, R M

Antiviral therapy, 2013-01, Vol.18, p.A6-A6 [Periódico revisado por pares]

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  • Título:
    Decreases in cholesterol in HIV-seronegative men using emtricitabine/tenofovir pre-exposure prophylaxis: lipid results of iPrEx
  • Autor: Mulligan, K ; Glidden, D V ; Anderson, P L ; McMahan, V ; Guanira, J V ; Lama, J R ; Buchbinder, S P ; Chariyalertsak, S ; Bekker, L-G ; Schechter, M ; Veloso, V G ; Wang, F ; Grant, R M
  • Assuntos: Human immunodeficiency virus
  • É parte de: Antiviral therapy, 2013-01, Vol.18, p.A6-A6
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    content type line 23
    ObjectType-Feature-1
  • Descrição: Daily use of oral emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) for pre-exposure prophylaxis (PrEP) decreases HIV acquisition. In HIV treatment, substitution of TDF or FTC/TDF for other antiretrovirals (ARV) or addition of TDF to an ARV regimen generally improves lipids, although decreases in HDL cholesterol have been seen. In a small study in seronegative subjects, 2 weeks' use of TDF decreased total and LDL cholesterol. We report the effects of prolonged treatment with FTC/TDF on lipids in the absence of HIV infection and other ARV use. In a metabolic substudy of iPrEx, an international randomized trial of PrEP in seronegative men who have sex with men, fasting serum samples for lipid measurements were collected at baseline and 24-week intervals and analysed centrally. In HIV-negative men taking FTC/TDF for PrEP, there were small but statistically significant across-the-board decreases in cholesterol that were most pronounced at week 24 and tended to rebound by week 72. These results demonstrate an effect of FTC/TDF on cholesterol that is independent of HIV suppression.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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