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Intestinal stromal cells in mucosal immunity and homeostasis

Owens, B M J ; Simmons, A

Mucosal immunology, 2013-03, Vol.6 (2), p.224-234 [Periódico revisado por pares]

United States: Nature Publishing Group

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Título:
Intestinal stromal cells in mucosal immunity and homeostasis
Autor: Owens, B M J ; Simmons, A
Assuntos: Animals ; B-Lymphocytes - immunology ; Cell Differentiation ; Granulocytes - immunology ; Homeostasis - immunology ; Humans ; Immunity, Mucosal ; Intestinal Mucosa - immunology ; Intestinal Mucosa - metabolism ; Lymphoid Tissue - immunology ; Myeloid Cells - cytology ; Stromal Cells - immunology ; Stromal Cells - metabolism ; T-Lymphocytes - immunology
É parte de: Mucosal immunology, 2013-03, Vol.6 (2), p.224-234
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: A growing body of evidence suggests that non-hematopoietic stromal cells of the intestine have multiple roles in immune responses and inflammation at this mucosal site. Despite this, many still consider gut stromal cells as passive structural entities, with past research focused heavily on their roles in fibrosis, tumor progression, and wound healing, rather than their contributions to immune function. In this review, we discuss our current knowledge of stromal cells in intestinal immunity, highlighting the many immunological axes in which stromal cells have a functional role. We also consider emerging data that broaden the potential scope of their contribution to immunity in the gut and argue that these so-called "non-immune" cells are reclassified in light of their diverse contributions to intestinal innate immunity and the maintenance of mucosal homeostasis.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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Intestinal stromal cells in mucosal immunity and homeostasis

Owens, B M J ; Simmons, A

United States: Nature Publishing Group

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