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Biomimetic Nanotechnology toward Personalized Vaccines

Zhou, Jiarong ; Kroll, Ashley V. ; Holay, Maya ; Fang, Ronnie H. ; Zhang, Liangfang

Advanced materials (Weinheim), 2020-04, Vol.32 (13), p.e1901255-n/a [Periódico revisado por pares]

Germany: Wiley Subscription Services, Inc

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Título:
Biomimetic Nanotechnology toward Personalized Vaccines
Autor: Zhou, Jiarong ; Kroll, Ashley V. ; Holay, Maya ; Fang, Ronnie H. ; Zhang, Liangfang
Assuntos: Animals ; Antibiotics ; anticancer vaccinations ; Antigens ; bacteria vaccinations ; Bacterial Infections - prevention & control ; Bacterial Vaccines - administration & dosage ; Bacterial Vaccines - therapeutic use ; Biomimetic Materials - chemistry ; biomimetic nanoparticles ; Biomimetics ; Biomimetics - methods ; Cancer Vaccines - administration & dosage ; Cancer Vaccines - therapeutic use ; Drug Delivery Systems - methods ; Humans ; Infectious diseases ; nanomedicine ; Nanomedicine - methods ; Nanoparticles - chemistry ; Nanotechnology ; Nanotechnology - methods ; Neoplasms - prevention & control ; personalized medicine ; Precision medicine ; Precision Medicine - methods ; Vaccination - methods ; Vaccines
É parte de: Advanced materials (Weinheim), 2020-04, Vol.32 (13), p.e1901255-n/a
Descrição: While traditional approaches for disease management in the era of modern medicine have saved countless lives and enhanced patient well‐being, it is clear that there is significant room to improve upon the current status quo. For infectious diseases, the steady rise of antibiotic resistance has resulted in super pathogens that do not respond to most approved drugs. In the field of cancer treatment, the idea of a cure‐all silver bullet has long been abandoned. As a result of the challenges facing current treatment and prevention paradigms in the clinic, there is an increasing push for personalized therapeutics, where plans for medical care are established on a patient‐by‐patient basis. Along these lines, vaccines, both against bacteria and tumors, are a clinical modality that could benefit significantly from personalization. Effective vaccination strategies could help to address many challenging disease conditions, but current vaccines are limited by factors such as a lack of potency and antigenic breadth. Recently, researchers have turned toward the use of biomimetic nanotechnology as a means of addressing these hurdles. Recent progress in the development of biomimetic nanovaccines for antibacterial and anticancer applications is discussed, with an emphasis on their potential for personalized medicine. Personalized medicine is transforming how diseases are managed in the clinic. At the same time, biomimetic nanotechnology offers many advantages that can be leveraged toward the design of more effective medical interventions. Recent developments in biomimetic nanovaccines against cancer and bacterial infections are discussed, with a specific emphasis on potential avenues for personalization.
Editor: Germany: Wiley Subscription Services, Inc
Idioma: Inglês

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Biomimetic Nanotechnology toward Personalized Vaccines

Zhou, Jiarong ; Kroll, Ashley V. ; Holay, Maya ; Fang, Ronnie H. ; Zhang, Liangfang

Germany: Wiley Subscription Services, Inc

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