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From canines to humans: Clinical importance of Staphylococcus pseudintermedius

Carroll, Karen C ; Burnham, Carey-Ann D ; Westblade, Lars F Kline, Kimberly A.

PLoS pathogens, 2021-12, Vol.17 (12), p.e1009961-e1009961 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
From canines to humans: Clinical importance of Staphylococcus pseudintermedius
Autor: Carroll, Karen C ; Burnham, Carey-Ann D ; Westblade, Lars F
Kline, Kimberly A.
Assuntos: Animals ; Antimicrobial agents ; Bacterial Zoonoses ; Biology and Life Sciences ; Care and treatment ; Cats ; Causes of ; Cell culture ; Cell walls ; Cloning ; Coagulase ; Coagulase - genetics ; Coagulase test ; Colonization ; Cytotoxins ; Dog Diseases - epidemiology ; Dog Diseases - microbiology ; Dogs ; Fibrin ; Fibrinogen ; Genetic aspects ; Humans ; Identification and classification ; Immune system ; Medicine and Health Sciences ; Pathogenicity ; Pathogens ; Pearls ; Pets ; Proteins ; Pyoderma ; Risk factors ; Sampling ; Skin ; Staphylococcal infections ; Staphylococcal Infections - epidemiology ; Staphylococcal Infections - microbiology ; Staphylococcus ; Staphylococcus - enzymology ; Staphylococcus - genetics ; Staphylococcus - pathogenicity ; Staphylococcus aureus ; Staphylococcus infections ; Superantigens ; Toxins ; Virulence ; Virulence factors ; Zoonoses
É parte de: PLoS pathogens, 2021-12, Vol.17 (12), p.e1009961-e1009961
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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The authors have declared that no competing interests exist.
Descrição: Introduction Historical observations led to the development of 2 important diagnostic assays: the classic tube coagulase test (in which fibrinogen is converted to fibrin by staphylocoagulase or von Willebrand binding protein, i.e., “free coagulase”) and the slide coagulase assay (whereby fibrinogen is bound by clumping factor, i.e., “bound coagulase”) [1,2]. In one study, enriched with individuals involved in the veterinary profession (42.5% of study participants), the prevalence (nasal colonization) of S. pseudintermedius in humans living in a household with a dog or cat was 4.1% (by contrast, the prevalence of S. aureus in humans was 27.7%), with lack of handwashing after handling household pets significantly associated with colonization [8]. [...]Guardabassi and colleagues demonstrated that owners of dogs with pyoderma were more likely to be culture positive for S. pseudintermedius compared to persons without daily contact with dogs, but colonization was not documented at the time of a second sampling 2 months later, suggesting that long-term colonization is uncommon in humans (although dogs were treated with antimicrobials after the first sampling, and most no longer had purulent lesions at the second sampling) [13]. What is the basis for S. pseudintermedius pathogenicity? S. pseudintermedius virulence factors include cytotoxins, exfoliative toxins, superantigens, and cell wall–associated (CWA) proteins and are important in initiating and spreading infections such as SSTIs and evading the immune system, and many are orthologous to those elaborated by S. aureus [7,14,25,26].
Editor: United States: Public Library of Science
Idioma: Inglês

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From canines to humans: Clinical importance of Staphylococcus pseudintermedius

Carroll, Karen C ; Burnham, Carey-Ann D ; Westblade, Lars F Kline, Kimberly A.

United States: Public Library of Science

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