Idioma:

Intraoperative transfusion practices and perioperative outcome in the European elderly: A secondary analysis of the observational ETPOS study

Grüßer, Linda ; Keszei, András ; Coburn, Mark ; Rossaint, Rolf ; Ziemann, Sebastian ; Kowark, Ana Wu, Wen-Chih

PloS one, 2022-01, Vol.17 (1), p.e0262110-e0262110 [Periódico revisado por pares]

United States: Public Library of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
Intraoperative transfusion practices and perioperative outcome in the European elderly: A secondary analysis of the observational ETPOS study
Autor: Grüßer, Linda ; Keszei, András ; Coburn, Mark ; Rossaint, Rolf ; Ziemann, Sebastian ; Kowark, Ana
Wu, Wen-Chih
Assuntos: Age groups ; Aged ; Aged patients ; Aged, 80 and over ; Analysis ; Anemia ; Anesthesiology ; Austria ; Blood ; Blood transfusion ; Care and treatment ; Clinical Decision-Making ; Demographics ; Elective Surgical Procedures ; Erythrocyte Transfusion - statistics & numerical data ; Erythrocytes ; Female ; Germany ; Hemoglobin ; Hospital patients ; Hospitals ; Humans ; Intensive care ; Intraoperative Care - statistics & numerical data ; Laboratories ; Length of stay ; Male ; Medicine and Health Sciences ; Methods ; Mortality ; Older people ; Outcome Assessment, Health Care ; Patient outcomes ; Patients ; People and Places ; Perioperative care ; Physiological aspects ; Population ; Practice ; Prospective Studies ; Red blood cells ; Romania ; Secondary analysis ; Spain ; Statistical analysis ; Surgery ; Transfusion ; United Kingdom
É parte de: PloS one, 2022-01, Vol.17 (1), p.e0262110-e0262110
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Undefined-3
Membership of The ETPOS Study Group is provided in the Acknowledgments.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: The demographic development suggests a dramatic growth in the number of elderly patients undergoing surgery in Europe. Most red blood cell transfusions (RBCT) are administered to older people, but little is known about perioperative transfusion practices in this population. In this secondary analysis of the prospective observational multicentre European Transfusion Practice and Outcome Study (ETPOS), we specifically evaluated intraoperative transfusion practices and the related outcomes of 3149 patients aged 65 years and older. Enrolled patients underwent elective surgery in 123 European hospitals, received at least one RBCT intraoperatively and were followed up for 30 days maximum. The mean haemoglobin value at the beginning of surgery was 108 (21) g/l, 84 (15) g/l before transfusion and 101 (16) g/l at the end of surgery. A median of 2 [1-2] units of RBCT were administered. Mostly, more than one transfusion trigger was present, with physiological triggers being preeminent. We revealed a descriptive association between each intraoperatively administered RBCT and mortality and discharge respectively, within the first 10 postoperative days but not thereafter. In our unadjusted model the hazard ratio (HR) for mortality was 1.11 (95% CI: 1.08-1.15) and the HR for discharge was 0.78 (95% CI: 0.74-0.83). After adjustment for several variables, such as age, preoperative haemoglobin and blood loss, the HR for mortality was 1.10 (95% CI: 1.05-1.15) and HR for discharge was 0.82 (95% CI: 0.78-0.87). Pre-operative anaemia in European elderly surgical patients is undertreated. Various triggers seem to support the decision for RBCT. A closer monitoring of elderly patients receiving intraoperative RBCT for the first 10 postoperative days might be justifiable. Further research on the causal relationship between RBCT and outcomes and on optimal transfusion strategies in the elderly population is warranted. A thorough analysis of different time periods within the first 30 postoperative days is recommended.
Editor: United States: Public Library of Science
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Intraoperative transfusion practices and perioperative outcome in the European elderly: A secondary analysis of the observational ETPOS study

Grüßer, Linda ; Keszei, András ; Coburn, Mark ; Rossaint, Rolf ; Ziemann, Sebastian ; Kowark, Ana Wu, Wen-Chih

United States: Public Library of Science

Buscando em bases de dados remotas. Favor aguardar.