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Structure of the human chromosome interaction network

Sarnataro, Sergio ; Chiariello, Andrea M ; Esposito, Andrea ; Prisco, Antonella ; Nicodemi, Mario Oliva, Baldo

PloS one, 2017-11, Vol.12 (11), p.e0188201-e0188201 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Structure of the human chromosome interaction network
Autor: Sarnataro, Sergio ; Chiariello, Andrea M ; Esposito, Andrea ; Prisco, Antonella ; Nicodemi, Mario
Oliva, Baldo
Assuntos: Biochemistry, Molecular Biology ; Biology and Life Sciences ; Chromosomes ; Computer and Information Sciences ; Deoxyribonucleic acid ; DNA ; Electric power distribution ; Epigenetics ; Gene expression ; Genomes ; Homology ; Human chromosomes ; Life Sciences ; Microscopy ; Nuclear electric power generation ; Nuclei ; Nuclei (cytology) ; Physics ; Physiological aspects ; Polymers ; Spatial distribution ; Structure ; Territory
É parte de: PloS one, 2017-11, Vol.12 (11), p.e0188201-e0188201
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC5687706
Competing Interests: The authors have declared that no competing interests exist.
Descrição: New Hi-C technologies have revealed that chromosomes have a complex network of spatial contacts in the cell nucleus of higher organisms, whose organisation is only partially understood. Here, we investigate the structure of such a network in human GM12878 cells, to derive a large scale picture of nuclear architecture. We find that the intensity of intra-chromosomal interactions is power-law distributed. Inter-chromosomal interactions are two orders of magnitude weaker and exponentially distributed, yet they are not randomly arranged along the genomic sequence. Intra-chromosomal contacts broadly occur between epigenomically homologous regions, whereas inter-chromosomal contacts are especially associated with regions rich in highly expressed genes. Overall, genomic contacts in the nucleus appear to be structured as a network of networks where a set of strongly individual chromosomal units, as envisaged in the 'chromosomal territory' scenario derived from microscopy, interact with each other via on average weaker, yet far from random and functionally important interactions.
Editor: United States: Public Library of Science
Idioma: Inglês

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Structure of the human chromosome interaction network

Sarnataro, Sergio ; Chiariello, Andrea M ; Esposito, Andrea ; Prisco, Antonella ; Nicodemi, Mario Oliva, Baldo

United States: Public Library of Science

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