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Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics

Quave, Cassandra L ; Estévez-Carmona, Miriam ; Compadre, Cesar M ; Hobby, Gerren ; Hendrickson, Howard ; Beenken, Karen E ; Smeltzer, Mark S Otto, Michael

PloS one, 2012-01, Vol.7 (1), p.e28737 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics
Autor: Quave, Cassandra L ; Estévez-Carmona, Miriam ; Compadre, Cesar M ; Hobby, Gerren ; Hendrickson, Howard ; Beenken, Karen E ; Smeltzer, Mark S
Otto, Michael
Assuntos: Acids ; Alternative medicine ; Animals ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotic Prophylaxis ; Antibiotics ; Antimicrobial agents ; Bacteria ; Bacterial infections ; Bioassays ; Biofilms ; Biofilms - drug effects ; Biofilms - growth & development ; Biological Assay ; Biological assays ; Biology ; Care and treatment ; Cell Death - drug effects ; Cell Line ; Cell lines ; Cells ; Cells (Biology) ; Chemical Fractionation ; Chemistry ; Chromatography, Liquid ; Clindamycin ; Cytotoxicity ; Daptomycin ; Derivatives ; Drug resistance in microorganisms ; Elaeocarpus ; Ellagic acid ; Ellagic Acid - chemistry ; Ellagic Acid - pharmacology ; Fatalities ; Fractionation ; Glycoproteins ; Glycosylation - drug effects ; Handbooks ; Health aspects ; Hepatocytes ; Herbal medicine ; Humans ; Immunology ; Infection ; Infections ; Infectious diseases ; Laboratories ; Liver ; Mammalian cells ; Mass Spectrometry ; Medical equipment ; Medicinal plants ; Medicine ; Mice ; Microbial drug resistance ; Microbial Sensitivity Tests ; Microscopy, Confocal ; Natural products ; Oxacillin ; Pathogenesis ; Pharmaceutical sciences ; Physiology ; Plant Extracts - chemistry ; Prevention ; Rosaceae ; Rosaceae - chemistry ; Rubus ulmifolius ; Skin ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - growth & development ; Staphylococcus aureus - physiology ; Staphylococcus aureus infections ; Staphylococcus infections ; Syzygium cumini ; Toxicity ; Turpinia
É parte de: PloS one, 2012-01, Vol.7 (1), p.e28737
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Conceived and designed the experiments: CLQ MEC CMC HH MSS KB. Performed the experiments: CLQ GH MEC HH. Analyzed the data: CLQ MSS CMC HH. Contributed reagents/materials/analysis tools: CLQ MSS CMC HH. Wrote the paper: CLQ MSS HH CMC.
Descrição: Biofilms contribute to the pathogenesis of many forms of Staphylococcus aureus infection. Treatment of these infections is complicated by intrinsic resistance to conventional antibiotics, thus creating an urgent need for strategies that can be used for the prevention and treatment of biofilm-associated infections. This study demonstrates that a botanical natural product composition (220D-F2) rich in ellagic acid and its derivatives can limit S. aureus biofilm formation to a degree that can be correlated with increased antibiotic susceptibility. The source of this composition is Rubus ulmifolius Schott. (Rosaceae), a plant used in complementary and alternative medicine in southern Italy for the treatment of skin and soft tissue infections. All S. aureus clonal lineages tested exhibited a reduced capacity to form a biofilm at 220D-F2 concentrations ranging from 50-200 µg/mL, which were well below the concentrations required to limit bacterial growth (530-1040 µg/mL). This limitation was therapeutically relevant in that inclusion of 220D-F2 resulted in enhanced susceptibility to the functionally-distinct antibiotics daptomycin, clindamycin and oxacillin. Testing with kidney and liver cell lines also demonstrated a lack of host cell cytotoxicity at concentrations of 220D-F2 required to achieve these effects. These results demonstrate that extract 220D-F2 from the root of Rubus ulmifolius can be used to inhibit S. aureus biofilm formation to a degree that can be correlated with increased antibiotic susceptibility without toxic effects on normal mammalian cells. Hence, 220D-F2 is a strong candidate for development as a botanical drug for use in the prevention and treatment of S. aureus biofilm-associated infections.
Editor: United States: Public Library of Science
Idioma: Inglês

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Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics

Quave, Cassandra L ; Estévez-Carmona, Miriam ; Compadre, Cesar M ; Hobby, Gerren ; Hendrickson, Howard ; Beenken, Karen E ; Smeltzer, Mark S Otto, Michael

United States: Public Library of Science

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