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Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model

Yang, Chenjie ; Kim, Seon-Hee ; Bianco, Nicole R ; Robbins, Paul D Kanellopoulos, Jean

PloS one, 2011-08, Vol.6 (8), p.e22517-e22517 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model
Autor: Yang, Chenjie ; Kim, Seon-Hee ; Bianco, Nicole R ; Robbins, Paul D
Kanellopoulos, Jean
Assuntos: Allergic reaction ; Allergy ; Analysis ; Animals ; Antigen (tumor-associated) ; Antigen presentation ; Antigen-antibody reactions ; Antigen-presenting cells ; Antigen-Presenting Cells - immunology ; Antigens ; Antigens, Neoplasm - immunology ; Arthritis ; Biology ; Cancer ; CD11c antigen ; Cytotoxicity ; Dendritic cells ; Drainage ; Exosomes ; Exosomes - immunology ; Hypersensitivity ; Hypersensitivity (delayed) ; Hypersensitivity, Delayed - immunology ; Immune response ; Immunosuppression ; Immunotherapy ; Interleukin 4 ; Interleukin-4 - genetics ; Lymphatic system ; Lymphocytes ; Medicine ; Melanoma ; Membrane vesicles ; Metastasis ; Mice ; mRNA ; Ovalbumin ; Ovalbumin - administration & dosage ; Proteins ; RNA, Messenger - genetics ; Transforming Growth Factor beta1 - biosynthesis ; Transforming Growth Factor beta1 - genetics ; Transforming growth factor-b1 ; Transforming growth factors ; Tumor antigens ; Tumor cells ; Tumors
É parte de: PloS one, 2011-08, Vol.6 (8), p.e22517-e22517
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: CY S-HK NRB PDR. Performed the experiments: CY S-HK NRB. Analyzed the data: CY S-HK NRB PDR. Contributed reagents/materials/analysis tools: CY S-HK NRB. Wrote the paper: CY PDR.
Descrição: Exosomes are endosome-derived small membrane vesicles that are secreted by most cell types including tumor cells. Tumor-derived exosomes usually contain tumor antigens and have been used as a source of tumor antigens to stimulate anti-tumor immune responses. However, many reports also suggest that tumor-derived exosomes can facilitate tumor immune evasion through different mechanisms, most of which are antigen-independent. In the present study we used a mouse model of delayed-type hypersensitivity (DTH) and demonstrated that local administration of tumor-derived exosomes carrying the model antigen chicken ovalbumin (OVA) resulted in the suppression of DTH response in an antigen-specific manner. Analysis of exosome trafficking demonstrated that following local injection, tumor-derived exosomes were internalized by CD11c+ cells and transported to the draining LN. Exosome-mediated DTH suppression is associated with increased mRNA levels of TGF-β1 and IL-4 in the draining LN. The tumor-derived exosomes examined were also found to inhibit DC maturation. Taken together, our results suggest a role for tumor-derived exosomes in inducing tumor antigen-specific immunosuppression, possibly by modulating the function of APCs.
Editor: United States: Public Library of Science
Idioma: Inglês

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Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model

Yang, Chenjie ; Kim, Seon-Hee ; Bianco, Nicole R ; Robbins, Paul D Kanellopoulos, Jean

United States: Public Library of Science

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