Idioma:

Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis

Van Kerkhove, Maria D ; Vandemaele, Katelijn A H ; Shinde, Vivek ; Jaramillo-Gutierrez, Giovanna ; Koukounari, Artemis ; Donnelly, Christl A ; Carlino, Luis O ; Owen, Rhonda ; Paterson, Beverly ; Pelletier, Louise ; Vachon, Julie ; Gonzalez, Claudia ; Hongjie, Yu ; Zijian, Feng ; Chuang, Shuk Kwan ; Au, Albert ; Buda, Silke ; Krause, Gerard ; Haas, Walter ; Bonmarin, Isabelle ; Taniguichi, Kiyosu ; Nakajima, Kensuke ; Shobayashi, Tokuaki ; Takayama, Yoshihiro ; Sunagawa, Tomi ; Heraud, Jean Michel ; Orelle, Arnaud ; Palacios, Ethel ; van der Sande, Marianne A B ; Wielders, C C H Lieke ; Hunt, Darren ; Cutter, Jeffrey ; Lee, Vernon J ; Thomas, Juno ; Santa-Olalla, Patricia ; Sierra-Moros, Maria J ; Hanshaoworakul, Wanna ; Ungchusak, Kumnuan ; Pebody, Richard ; Jain, Seema ; Mounts, Anthony W Peiris, J. S. Malik

PLoS medicine, 2011-07, Vol.8 (7), p.e1001053 [Periódico revisado por pares]

United States: Public Library of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis
Autor: Van Kerkhove, Maria D ; Vandemaele, Katelijn A H ; Shinde, Vivek ; Jaramillo-Gutierrez, Giovanna ; Koukounari, Artemis ; Donnelly, Christl A ; Carlino, Luis O ; Owen, Rhonda ; Paterson, Beverly ; Pelletier, Louise ; Vachon, Julie ; Gonzalez, Claudia ; Hongjie, Yu ; Zijian, Feng ; Chuang, Shuk Kwan ; Au, Albert ; Buda, Silke ; Krause, Gerard ; Haas, Walter ; Bonmarin, Isabelle ; Taniguichi, Kiyosu ; Nakajima, Kensuke ; Shobayashi, Tokuaki ; Takayama, Yoshihiro ; Sunagawa, Tomi ; Heraud, Jean Michel ; Orelle, Arnaud ; Palacios, Ethel ; van der Sande, Marianne A B ; Wielders, C C H Lieke ; Hunt, Darren ; Cutter, Jeffrey ; Lee, Vernon J ; Thomas, Juno ; Santa-Olalla, Patricia ; Sierra-Moros, Maria J ; Hanshaoworakul, Wanna ; Ungchusak, Kumnuan ; Pebody, Richard ; Jain, Seema ; Mounts, Anthony W
Peiris, J. S. Malik
Assuntos: Adolescent ; Adult ; Age ; Aged ; Biochemistry, Molecular Biology ; Body Mass Index ; Child ; Child, Preschool ; Chronic Disease ; Chronic Disease - epidemiology ; Chronic Disease - mortality ; Data Interpretation, Statistical ; Development and progression ; Disease control ; Emerging diseases ; Epidemiology ; Female ; Global Health ; Health aspects ; Health facilities ; Hospitalization ; Hospitalization - statistics & numerical data ; Hospitals ; Human health and pathology ; Humans ; Infections ; Infectious diseases ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H1N1 Subtype - pathogenicity ; Influenza, Human ; Influenza, Human - epidemiology ; Influenza, Human - mortality ; Influenza, Human - virology ; Intensive Care Units ; Intensive Care Units - statistics & numerical data ; Laboratories ; Life Sciences ; Male ; Medicine ; Microbiology and Parasitology ; Middle Aged ; Molecular biology ; Obesity ; Odds Ratio ; Pandemics ; Pandemics - statistics & numerical data ; Pregnancy ; Pregnant women ; Prevalence ; Public health ; Risk Factors ; Santé publique et épidémiologie ; Swine influenza ; Virology ; Womens health ; Young Adult
É parte de: PLoS medicine, 2011-07, Vol.8 (7), p.e1001053
Notas: Conceived and designed the experiments: AWM MDVK KAHV VS GJG. Analyzed the data: MDVK KAHV VS GJG AWM CAD AK. Wrote the paper: MDVK KAHV VS GJG AWM. ICMJE criteria for authorship read and met: MDVK KAHV VS GJG LOC RO LP JV CG YH FZ SKC AA SB GK WH IB KT KN TS YT TS JMH AO EP MABV LW DH JC VJL JT PSO MJS WH JKU RP SJ AWM CAD AK. Agree with the manuscript's results and conclusions: MDVK KAHV VS GJG LOC RO LP JV CG YH FZ SKC AA SB GK WH IB KT KN TS YT TS JMH AO EP MABV LW DH JC VJL JT PSO MJS WH JKU RP SJ AWM CAD AK. Wrote the first draft of the paper: MDVK KAHV VS GJG AWM. Reviewed and edited several versions of the manuscript: LOC RO LP JV CG YH FZ SKC AA SB GK WH IB KT KN TS YT TS JMH AO EP MABV LW DH JC VJL JT PSO MJS WH JKU RP SJ.
Descrição: Since the start of the 2009 influenza A pandemic (H1N1pdm), the World Health Organization and its member states have gathered information to characterize the clinical severity of H1N1pdm infection and to assist policy makers to determine risk groups for targeted control measures. Data were collected on approximately 70,000 laboratory-confirmed hospitalized H1N1pdm patients, 9,700 patients admitted to intensive care units (ICUs), and 2,500 deaths reported between 1 April 2009 and 1 January 2010 from 19 countries or administrative regions--Argentina, Australia, Canada, Chile, China, France, Germany, Hong Kong SAR, Japan, Madagascar, Mexico, The Netherlands, New Zealand, Singapore, South Africa, Spain, Thailand, the United States, and the United Kingdom--to characterize and compare the distribution of risk factors among H1N1pdm patients at three levels of severity: hospitalizations, ICU admissions, and deaths. The median age of patients increased with severity of disease. The highest per capita risk of hospitalization was among patients <5 y and 5-14 y (relative risk [RR] = 3.3 and 3.2, respectively, compared to the general population), whereas the highest risk of death per capita was in the age groups 50-64 y and ≥65 y (RR = 1.5 and 1.6, respectively, compared to the general population). Similarly, the ratio of H1N1pdm deaths to hospitalizations increased with age and was the highest in the ≥65-y-old age group, indicating that while infection rates have been observed to be very low in the oldest age group, risk of death in those over the age of 64 y who became infected was higher than in younger groups. The proportion of H1N1pdm patients with one or more reported chronic conditions increased with severity (median = 31.1%, 52.3%, and 61.8% of hospitalized, ICU-admitted, and fatal H1N1pdm cases, respectively). With the exception of the risk factors asthma, pregnancy, and obesity, the proportion of patients with each risk factor increased with severity level. For all levels of severity, pregnant women in their third trimester consistently accounted for the majority of the total of pregnant women. Our findings suggest that morbid obesity might be a risk factor for ICU admission and fatal outcome (RR = 36.3). Our results demonstrate that risk factors for severe H1N1pdm infection are similar to those for seasonal influenza, with some notable differences, such as younger age groups and obesity, and reinforce the need to identify and protect groups at highest risk of severe outcomes. Please see later in the article for the Editors' Summary.
Editor: United States: Public Library of Science
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis

United States: Public Library of Science

Buscando em bases de dados remotas. Favor aguardar.