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Production of arachidonic and linoleic acid metabolites by Guinea pig tracheal epithelial cells

OOSTHUIZEN, M. J ; ENGELS, F ; VAN ESCH, B ; HENRICKS, P. A. J ; NIJKAMP, F. P

Inflammation, 1990-08, Vol.14 (4), p.401-408 [Periódico revisado por pares]

New York, NY: Springer

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Título:
Production of arachidonic and linoleic acid metabolites by Guinea pig tracheal epithelial cells
Autor: OOSTHUIZEN, M. J ; ENGELS, F ; VAN ESCH, B ; HENRICKS, P. A. J ; NIJKAMP, F. P
Assuntos: 550201 - Biochemistry- Tracer Techniques ; ANIMAL TISSUES ; ANIMALS ; Antithrombins - biosynthesis ; ARACHIDONIC ACID ; Arachidonic Acids - metabolism ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; BODY ; CARBON ISOTOPES ; Carbon Radioisotopes ; CARBOXYLIC ACIDS ; Epithelial Cells ; EPITHELIUM ; Epithelium - metabolism ; Fatty Acids - metabolism ; Fundamental and applied biological sciences. Psychology ; GUINEA PIGS ; Hydroxyeicosatetraenoic Acids - biosynthesis ; Inflammation ; ISOTOPE APPLICATIONS ; ISOTOPES ; LINOLEIC ACID ; Linoleic Acids - biosynthesis ; Linoleic Acids - metabolism ; Linoleic Acids, Conjugated ; Male ; MAMMALS ; METABOLISM ; Molecular and cellular biology ; MONOCARBOXYLIC ACIDS ; MUSCLES ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; Perfusion ; RESPIRATORY SYSTEM ; RODENTS ; TISSUES ; TRACER TECHNIQUES ; TRACHEA ; Trachea - metabolism ; VERTEBRATES
É parte de: Inflammation, 1990-08, Vol.14 (4), p.401-408
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Pulmonary epithelial cells may be responsible for regulating airway smooth muscle function, in part by release of fatty acid-derived mediators. Incubation of isolated guinea pig tracheal epithelial cells with radiolabeled arachidonic acid (AA) leads to the production of 5- and 15-hydroxyeicosatetraenoic acid (5- and 15-HETE) and smaller amounts of leukotriene (LT) B4 and C4 and 12-hydroxyheptadecatrienoic acid (HHT). Epithelial cells also are able to release linoleic acid (LA) metabolites. Incubation with radiolabeled linoleic acid leads to the formation of 9- and 13-hydroxyoctadecadienoic acid (9- and 13-HODE). The biological significance of these mediators produced by epithelial cells is discussed.
Editor: New York, NY: Springer
Idioma: Inglês

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Production of arachidonic and linoleic acid metabolites by Guinea pig tracheal epithelial cells

OOSTHUIZEN, M. J ; ENGELS, F ; VAN ESCH, B ; HENRICKS, P. A. J ; NIJKAMP, F. P

New York, NY: Springer

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