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The impact of hypoxia-inducible factors in the pathogenesis of kidney diseases: a link through cell metabolism

Orestes Foresto-neto ; Ana Ruth Paolinetti Alves Da Silva ; Marcella Cipelli ; Fernanda Paula Roncon Santana-novelli ; Niels Olsen Saraiva Camara

Kidney research and clinical practice, 2023-09, Vol.42 (5), p.561-578 [Periódico revisado por pares]

대한신장학회

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  • Título:
    The impact of hypoxia-inducible factors in the pathogenesis of kidney diseases: a link through cell metabolism
  • Autor: Orestes Foresto-neto ; Ana Ruth Paolinetti Alves Da Silva ; Marcella Cipelli ; Fernanda Paula Roncon Santana-novelli ; Niels Olsen Saraiva Camara
  • Assuntos: Immune system ; Lung injury ; Metabolismx ; Microbiota
  • É parte de: Kidney research and clinical practice, 2023-09, Vol.42 (5), p.561-578
  • Notas: The Korean Society of Nephrology
  • Descrição: Kidneys are sensitive to disturbances in oxygen homeostasis. Hypoxia and activation of the hypoxia-inducible factor (HIF) pathway alter the expression of genes involved in the metabolism of renal and immune cells, interfering with their functioning. Whether the transcriptional activity of HIF protects the kidneys or participates in the pathogenesis of renal diseases is unclear. Several studies have indicated that HIF signaling promotes fibrosis in experimental models of kidney disease. Other reports showed a protective effect of HIF activation on kidney inflammation and injury. In addition to the direct effect of HIF on the kidneys, experimental evidence indicates that HIF-mediated metabolic shift activates inflammatory cells, supporting the HIF cascade as a link between lung or gut damage and worsening of renal disease. Although hypoxia and HIF activation are present in several scenarios of renal diseases, further investigations are needed to clarify whether interfering with the HIF pathway is beneficial in different pathological contexts.
  • Editor: 대한신장학회
  • Idioma: Coreano
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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