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Association of Metabolic Syndrome with COVID-19 in the Republic of Korea

Woo-hwi Jeon ; Jeong-yeon Seon ; So-youn Park ; In-hwan Oh

Diabetes & metabolism journal, 2022-05, Vol.46 (3), p.427-438 [Periódico revisado por pares]

대한당뇨병학회

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  • Título:
    Association of Metabolic Syndrome with COVID-19 in the Republic of Korea
  • Autor: Woo-hwi Jeon ; Jeong-yeon Seon ; So-youn Park ; In-hwan Oh
  • Assuntos: COVID-19 ; Metabolic syndrome ; Risk factors
  • É parte de: Diabetes & metabolism journal, 2022-05, Vol.46 (3), p.427-438
  • Notas: Korean Diabetes Association
  • Descrição: Background: Metabolic syndrome (MetS) is reportedly a crucial risk factor for coronavirus disease 2019 (COVID-19). Since the epidemiological studies that examine this association are few and include small samples, we investigated the relationship between MetS and COVID-19 severity and death using a larger sample in the Republic of Korea. Methods: We analyzed 66,321 patients, 4,066 of whom had COVID-19. We used chi-square tests to examine patients’ characteristics. We performed logistic regression analysis to analyze differences in COVID-19 infection and clinical outcomes according to the presence of MetS. Results: Although MetS was not significantly associated with COVID-19 risk, acquiring MetS was significantly associated with the risk of severe COVID-19 outcomes (odds ratio [OR], 1.97; 95% confidence interval [CI], 1.34 to 2.91; P=0.001). The mortality risk was significantly higher in COVID-19 patients with MetS (OR, 1.74; 95% CI, 1.17 to 2.59; P=0.006). Patients with abnormal waist circumference were approximately 2.07 times more likely to develop severe COVID-19 (P<0.001), and high-density lipoprotein cholesterol (HDL-C) levels were significantly associated with COVID-19; the mortality risk due to COVID-19 was 1.74 times higher in men with an HDL-C level of <40 mg/dL and in women with an HDL-C level of <50 mg/dL (P=0.012). Conclusion: COVID-19 is likely associated with severity and death in patients with MetS or in patients with MetS risk factors. Therefore, patients with MetS or those with abnormal waist circumference and HDL-C levels need to be treated with caution.
  • Editor: 대한당뇨병학회
  • Idioma: Coreano

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