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Sensitivity of field isolates of Eimeria acervulina and E. maxima from three regions in Brazil to eight anticoccidial drugs

Kraieski, A.L. ; Salles, G.B.C. ; Muniz, E.C. ; Nascimento, D.V.J. ; Lima Neto, A.J. ; Santos, I.L. ; Madeira, A.M.B.N.

Poultry science, 2021-08, Vol.100 (8), p.101233-101233, Article 101233 [Periódico revisado por pares]

Elsevier Inc

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  • Título:
    Sensitivity of field isolates of Eimeria acervulina and E. maxima from three regions in Brazil to eight anticoccidial drugs
  • Autor: Kraieski, A.L. ; Salles, G.B.C. ; Muniz, E.C. ; Nascimento, D.V.J. ; Lima Neto, A.J. ; Santos, I.L. ; Madeira, A.M.B.N.
  • Assuntos: anticoccidial drug ; anticoccidial resistance ; anticoccidial sensitivity test ; broiler chicken ; coccidiosis ; IMMUNOLOGY, HEALTH AND DISEASE
  • É parte de: Poultry science, 2021-08, Vol.100 (8), p.101233-101233, Article 101233
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: Rotation with different active ingredients is among the most effective and recommended strategies to preserve the efficacy of anticoccidial drugs and reduce the emergence of resistance. Tools such as anticoccidial sensitivity tests (ASTs) are ideally used to make rational rotation programs and bring benefits to production. The objective of this study was to evaluate the sensitivity of E. acervulina (EA) and E. maxima (EM) from 3 different regions in Brazil, by using four ASTs. Feces samples weighing 6 to 7 kg were collected in the regions of São Paulo, Paraná, and Minas Gerais. Prevalent oocysts from feces were filtered, identified, and quantified to conduct 2 ASTs with EA and 2 with EM. The same experimental design was used in every AST (4 replicates per treatment, with 6 birds each, for a total of 240 birds). Treatment groups were a nonchallenged and nonmedicated control group (T1), a challenged and nonmedicated control group (T2), and the other groups challenged and treated with the following compounds: lasalocid (90 ppm – T3), maduramycin (6 ppm – T4), decoquinate (30 ppm – T5), nicarbazin+semduramicin (66 ppm – T6), monensin (110 ppm – T7), salinomycin (66 ppm – T8), narasin+nicarbazin (100 ppm – T9), and nicarbazin (125 ppm – T10). At the end of each AST (20 d), the percent change (delta value) between the treated group (T3 to T10) and the control group (T2) was calculated for the following variables: body weight gain, feed conversion ratio, lesion score, and an indicator of percentage of optimal anticoccidial activity (POAA) that included T2. Different sensitivity levels of EA and EM isolates could be identified. As a whole, drugs from T5 and T3 groups showed higher delta values when compared to other compounds, whereas the lowest sensitivity levels of these isolates were observed in groups T4 and T7. Despite some limiting factors, ASTs can be a good tool for strategic selection of anticoccidial drugs in order to maintain efficacy and extend the lifespan of these molecules.
  • Editor: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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