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Comparison of virulence-related determinants between the ST59-t437 and ST239-t030 genotypes of methicillin-resistant Staphylococcus aureus

Liao, Feng ; Gu, Wenpeng ; Fu, Xiaoqing ; Yuan, Bin ; Zhang, Yunhui

BMC microbiology, 2021-10, Vol.21 (1), p.264-264, Article 264 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Comparison of virulence-related determinants between the ST59-t437 and ST239-t030 genotypes of methicillin-resistant Staphylococcus aureus
Autor: Liao, Feng ; Gu, Wenpeng ; Fu, Xiaoqing ; Yuan, Bin ; Zhang, Yunhui
Assuntos: Adhesion ; Adhesive strength ; Analysis ; Animal experimentation ; Animals ; Antibiotics ; Biocompatibility ; Biofilms ; Causes of ; China ; Cloning ; Community-Acquired Infections - microbiology ; Comparative analysis ; Cross infection ; Cross Infection - microbiology ; Cytotoxicity ; Drug resistance ; Drug resistance in microorganisms ; Epidemics ; Exudation ; Genes ; Genetic aspects ; Genotype ; Genotype & phenotype ; Genotypes ; Health aspects ; Humans ; Identification and classification ; Infection ; Infections ; Inflammation ; Japan ; Methicillin ; Methicillin-resistant Staphylococcus aureus ; Methicillin-Resistant Staphylococcus aureus - genetics ; Mice ; Mice, Inbred BALB C ; Nosocomial infections ; Organs ; Pathogenic ability ; Pathogens ; Phenotypic ; Public health ; Risk factors ; ST239-t030 ; ST59-t437 ; Staphylococcal infections ; Staphylococcal Infections - microbiology ; Staphylococcus aureus ; Staphylococcus infections ; Strains (organisms) ; Survival ; Survival Analysis ; Toxicity ; Toxins ; Virulence ; Virulence (Microbiology) ; Virulence Factors - genetics
É parte de: BMC microbiology, 2021-10, Vol.21 (1), p.264-264, Article 264
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SourceType-Scholarly Journals-1
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Descrição: Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen for human infection. Hospital-acquired (HA) and community-acquired (CA) MRSA infections are serious clinical problems worldwide. In this study, we selected typical HA-MRSA strain and CA-MRSA isolates from our previous research and compared their phenotypic and pathogenic abilities both in vitro and in vivo. ST59-t437-SCCmecIVa (YNSA7) and ST59-t437-SCCmecVb (YNSA53) belonged to two prevalent subclones of CA-MRSA, while ST239-t030-SCCmecIII (YNSA163) was an HA-MRSA epidemic clone in Southwest China. ST59-t437 strains demonstrated faster growth ability, higher survival rate resistance to human blood, and more toxin secretion levels and cytotoxicity than ST239-t030. The virulence and regulatory genes of hld, psm-α, RNAIII, agrA, and crtN were highly expressed on CA-MRSA isolates, especially the ST59-t437-SCCmecIVa subclone. However, the ST239-t030 strain had the strongest adhesion and biofilm ability among these MRSA bacteria. Animal experiments revealed the most serious lethal effect on BALB/c mice caused by the YNSA7 strain infection. The survival rates of BALB/c mice infected with the three MRSA strains were 16.7, 50.0 and 100.0% for YNSA7, YNSA53 and YNSA163, respectively. Histopathological analyses of infected animals indicated that the lungs were the most seriously damaged organs, especially for ST59-t437 MRSA. Severe inflammatory reactions, tissue destruction, and massive exudation of inflammatory mediators and cells could be identified in ST59-t437 strain-infected animals. In general, ST59-t437 strains showed higher pathogenic ability than the ST239-t030 isolate, while ST239-t030 MRSA revealed the features prevalent in hospital settings, specifically for adhesion and biofilm ability.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Comparison of virulence-related determinants between the ST59-t437 and ST239-t030 genotypes of methicillin-resistant Staphylococcus aureus

Liao, Feng ; Gu, Wenpeng ; Fu, Xiaoqing ; Yuan, Bin ; Zhang, Yunhui

England: BioMed Central Ltd

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