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Comparison of Cryptococcus gattii / neoformans Species Complex to Related Genera ( Papiliotrema and Naganishia ) Reveal Variances in Virulence Associated Factors and Antifungal Susceptibility

Oliveira, Lana Sarita de Souza ; Pinto, Luciana Magalhães ; de Medeiros, Mariana Araújo Paulo ; Toffaletti, Dena L ; Tenor, Jennifer L ; Barros, Tânia Fraga ; Neves, Rejane Pereira ; Neto, Reginaldo Gonçalves de Lima ; Milan, Eveline Pipolo ; Padovan, Ana Carolina Barbosa ; Rocha, Walicyranison Plinio da Silva ; Perfect, John R ; Chaves, Guilherme Maranhão

Frontiers in cellular and infection microbiology, 2021-07, Vol.11, p.642658-642658 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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  • Título:
    Comparison of Cryptococcus gattii / neoformans Species Complex to Related Genera ( Papiliotrema and Naganishia ) Reveal Variances in Virulence Associated Factors and Antifungal Susceptibility
  • Autor: Oliveira, Lana Sarita de Souza ; Pinto, Luciana Magalhães ; de Medeiros, Mariana Araújo Paulo ; Toffaletti, Dena L ; Tenor, Jennifer L ; Barros, Tânia Fraga ; Neves, Rejane Pereira ; Neto, Reginaldo Gonçalves de Lima ; Milan, Eveline Pipolo ; Padovan, Ana Carolina Barbosa ; Rocha, Walicyranison Plinio da Silva ; Perfect, John R ; Chaves, Guilherme Maranhão
  • Assuntos: Antifungal Agents - pharmacology ; antifungal drug susceptibility ; Basidiomycota ; Cellular and Infection Microbiology ; Cryptococcus gattii ; Cryptococcus neoformans ; Cryptococcus spp ; Humans ; Naganishia spp ; Papiliotrema laurentii ; Virulence ; Virulence Factors
  • É parte de: Frontiers in cellular and infection microbiology, 2021-07, Vol.11, p.642658-642658
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Reviewed by: Sudha Chaturvedi, Wadsworth Center, United States; Jianping Xu, McMaster University, Canada
    Edited by: Brian Wickes, The University of Texas Health Science Center at San Antonio, United States
    This article was submitted to Fungal Pathogenesis, a section of the journal Frontiers in Cellular and Infection Microbiology
  • Descrição: Cryptococcosis is an infectious disease of worldwide distribution, caused by encapsulated yeasts belonging to the phylum Basidiomycota. The genus includes several species distributed around the world. The / species complex is largely responsible for most cases of cryptococcosis. However, clinical series have been published of infections caused by ( ) and ( ), among other related genera. Here, we examined the pathogenic potential and antifungal susceptibility of / species complex (clades I and II) and related genera ( and ) isolated from environmental and clinical samples. . (clade III), . (clade IV) and / . (clade V) strains produced higher levels of phospholipase and hemolysins, whereas the / species complex strains (clades I and II) had markedly thicker capsules, produced more biofilm biomass and melanin, which are known virulence attributes. Interestingly, 40% of . strains (clade II) had MICs above the ECV established for this species to amphotericin B. Several non- / species complex (clades III to V) had MICs equal to or above the ECVs established for and for all the three antifungal drugs tested. Finally, all the non- clinical isolates (clades III to V) produced more melanin than the environmental isolates might reflect their particularly enhanced need for melanin during protection. It is very clear that / species complex (clades I and II) strains, in general, show more similar virulence phenotypes between each other when compared to non- / species complex (clades III to V) isolates. These observations together with the fact that . and spp. (clades III to V) strains were collected from the outside of a University Hospital, identify features of these yeasts important for environmental and patient colonization and furthermore, define mechanisms for infections with these uncommon pathogens.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
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