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Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies

Okba, Nisreen M A ; Widjaja, Ivy ; Li, Wentao ; GeurtsvanKessel, Corine H ; Farag, Elmoubasher A B A ; Al-Hajri, Mohammed ; Park, Wan Beom ; Oh, Myoung-Don ; Reusken, Chantal B E M ; Koopmans, Marion P G ; Bosch, Berend-Jan ; Haagmans, Bart L

Emerging infectious diseases, 2020-05, Vol.26 (5), p.1024-1027 [Periódico revisado por pares]

United States: U.S. National Center for Infectious Diseases

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Título:
Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies
Autor: Okba, Nisreen M A ; Widjaja, Ivy ; Li, Wentao ; GeurtsvanKessel, Corine H ; Farag, Elmoubasher A B A ; Al-Hajri, Mohammed ; Park, Wan Beom ; Oh, Myoung-Don ; Reusken, Chantal B E M ; Koopmans, Marion P G ; Bosch, Berend-Jan ; Haagmans, Bart L
Assuntos: Antibodies ; Archives & records ; Biopharmaceuticals ; Biosafety ; Coronaviruses ; Epidemics ; Glycoproteins ; Health care ; hemagglutination ; Infections ; Laboratories ; lumazine synthase ; MERS ; Middle East respiratory syndrome ; Middle East respiratory syndrome coronavirus ; neutralization ; Organic acids ; Proteins ; Recombinant proteins ; Research Letter ; Respiratory diseases ; Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies ; Vaccines ; Viruses ; Zoonoses
É parte de: Emerging infectious diseases, 2020-05, Vol.26 (5), p.1024-1027
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.
Editor: United States: U.S. National Center for Infectious Diseases
Idioma: Inglês

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Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies

Okba, Nisreen M A ; Widjaja, Ivy ; Li, Wentao ; GeurtsvanKessel, Corine H ; Farag, Elmoubasher A B A ; Al-Hajri, Mohammed ; Park, Wan Beom ; Oh, Myoung-Don ; Reusken, Chantal B E M ; Koopmans, Marion P G ; Bosch, Berend-Jan ; Haagmans, Bart L

United States: U.S. National Center for Infectious Diseases

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