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Insights into Sensing of Murine Retroviruses
Moran, Eileen A ; Ross, Susan R
Viruses, 2020-07, Vol.12 (8), p.836
[Periódico revisado por pares]
Switzerland: MDPI AG
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Título:
Insights into Sensing of Murine Retroviruses
Autor:
Moran, Eileen A
;
Ross, Susan R
Assuntos:
Adaptive immunity
;
ALR
;
Animals
;
Binding sites
;
Breast cancer
;
Cytokines
;
Deoxyribonucleic acid
;
DNA
;
Genes
;
Host Microbial Interactions - immunology
;
Immune response
;
Immune system
;
Immunity, Innate
;
Infections
;
Innate immunity
;
Kinases
;
Leukemia
;
Ligands
;
Mice - virology
;
mouse mammary tumor virus
;
murine leukemia virus
;
PAMP
;
Pathogens
;
Proteins
;
PRR
;
Retroviridae - genetics
;
Retroviridae - immunology
;
Retroviridae Infections - immunology
;
Retroviridae Infections - virology
;
Review
;
RNA polymerase
;
TLR
;
Toll-like receptors
;
Virus Replication
;
Viruses
;
West Nile virus
É parte de:
Viruses, 2020-07, Vol.12 (8), p.836
Notas:
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
Descrição:
Retroviruses are major causes of disease in animals and human. Better understanding of the initial host immune response to these viruses could provide insight into how to limit infection. Mouse retroviruses that are endemic in their hosts provide an important genetic tool to dissect the different arms of the innate immune system that recognize retroviruses as foreign. Here, we review what is known about the major branches of the innate immune system that respond to mouse retrovirus infection, Toll-like receptors and nucleic acid sensors, and discuss the importance of these responses in activating adaptive immunity and controlling infection.
Editor:
Switzerland: MDPI AG
Idioma:
Inglês
Links
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