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Impact of sucroferric oxyhydroxide on the oral and intestinal microbiome in hemodialysis patients

Abdelbary, Mohamed M H ; Kuppe, Christoph ; Michael, Sareh Said-Yekta ; Krüger, Thilo ; Floege, Jürgen ; Conrads, Georg

Scientific reports, 2022-06, Vol.12 (1), p.9614-9614, Article 9614 [Periódico revisado por pares]

England: Nature Publishing Group

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Impact of sucroferric oxyhydroxide on the oral and intestinal microbiome in hemodialysis patients
Autor: Abdelbary, Mohamed M H ; Kuppe, Christoph ; Michael, Sareh Said-Yekta ; Krüger, Thilo ; Floege, Jürgen ; Conrads, Georg
Assuntos: Cardiovascular diseases ; Dental plaque ; Drug Combinations ; Ferric Compounds - pharmacology ; Ferric Compounds - therapeutic use ; Gastrointestinal Microbiome ; Hemodialysis ; Humans ; Hyperphosphatemia ; Iron ; Kidney diseases ; Microbiomes ; Patients ; Phosphates ; Renal Dialysis - adverse effects ; RNA, Ribosomal, 16S - genetics ; rRNA 16S ; Saliva ; Siderophores ; Sucrose - pharmacology
É parte de: Scientific reports, 2022-06, Vol.12 (1), p.9614-9614, Article 9614
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Descrição: Hyperphosphatemia is a consequence of chronic kidney disease associated with mineral/bone impairment, increased cardiovascular events and mortality. Therapeutically, most dialysis patients have to take phosphate binders. Here, we investigated effects of the Fe(3+)-based phosphate binder sucroferric oxyhydroxide (SFOH) on the oral and gastrointestinal microbiome of 11 hemodialysis patients. Saliva, dental plaque and stool were collected at baseline, one and four weeks of SFOH intake and subjected to 16S rRNA gene (V3-V4 region) directed Illumina MiSeq-based analysis. Total Fe, Fe(2+) and Fe(3+) were determined in stool and saliva. Overall, the microbiome did not change significantly. However, some patient-, sample- and taxon-specific differences were noted, which allowed patients to be divided into those with a shift in their microbiome (6/11) and those without a shift (5/11). Total Fe and Fe(2+) were highest after one week of SFOH, particularly in patients who exhibited a shift in microbiome composition. Eight bacterial taxa showed significant unidirectional changes during treatment. In-depth microbiome analysis revealed that taxa that significantly benefited from iron plethora had no iron-binding siderophores or alternatives, which was in contrast to taxa that significantly declined under iron plethora. Patients with microbiome-shift were significantly younger and had higher serum phosphate concentrations. In conclusion, this study sheds light on the impact of iron on the microbiome of hemodialysis patients.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Impact of sucroferric oxyhydroxide on the oral and intestinal microbiome in hemodialysis patients

Abdelbary, Mohamed M H ; Kuppe, Christoph ; Michael, Sareh Said-Yekta ; Krüger, Thilo ; Floege, Jürgen ; Conrads, Georg

England: Nature Publishing Group

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