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On Naevi and Melanomas: Two Sides of the Same Coin?

Lee, Katie J ; Janda, Monika ; Stark, Mitchell S ; Sturm, Richard A ; Soyer, H Peter

Frontiers in medicine, 2021-02, Vol.8, p.635316 [Periódico revisado por pares]

Switzerland: Frontiers Research Foundation

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  • Título:
    On Naevi and Melanomas: Two Sides of the Same Coin?
  • Autor: Lee, Katie J ; Janda, Monika ; Stark, Mitchell S ; Sturm, Richard A ; Soyer, H Peter
  • Assuntos: artificial intelligence ; genetics and genomics ; Medicine ; Melanoma ; precancer ; precursor lesion ; risk stratification
  • É parte de: Frontiers in medicine, 2021-02, Vol.8, p.635316
  • Notas: This article was submitted to Dermatology, a section of the journal Frontiers in Medicine
    Edited by: Youwen Zhou, University of British Columbia, Canada
    Reviewed by: Remco Van Doorn, Leiden University Medical Center, Netherlands; Irina Khamaganova, Pirogov Russian National Research Medical University, Russia
  • Descrição: Benign naevi are closely linked to melanoma, as risk factors, simulators, or sites of melanoma formation. There is a heavy genetic overlap between the two lesions, a shared environmental influence of ultraviolet radiation, and many similar cellular features, yet naevi remain locally situated while melanomas spread from their primary site and may progress systemically to distal organs. Untangling the overlapping contributors and predictors of naevi and melanoma is an ongoing area of research and should eventually lead to more personalized prevention and treatment strategies, through the development of melanoma risk stratification tools and early detection of evolving melanomas. This will be achieved through a range of complementary strategies: risk-adjusted primary prevention counseling; the use of lesion imaging technologies such as sequential 3D total body photography and consumer-performed lesion imaging; artificial intelligence deep phenotyping and clinical assistance; a better understanding of genetic drivers of malignancy, risk variants, clinical genetics, and polygenic effects; and the interplay between genetics, phenotype and the environment.
  • Editor: Switzerland: Frontiers Research Foundation
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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