skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Behavior of ACRBP-deficient mouse sperm in the female reproductive tract

NAGASHIMA, Kiyoshi ; USUI, Tomoyuki ; BABA, Tadashi

Journal of Reproduction and Development, 2019, Vol.65(2), pp.97-102 [Periódico revisado por pares]

Tokyo: THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT

Texto completo disponível

Citações Citado por
  • Título:
    Behavior of ACRBP-deficient mouse sperm in the female reproductive tract
  • Autor: NAGASHIMA, Kiyoshi ; USUI, Tomoyuki ; BABA, Tadashi
  • Assuntos: ACRBP ; Acrosome reaction ; Female reproductive tract ; Fertility ; Fertilization ; Mating ; Migration ; Mouse ; Oocytes ; Original ; Oviduct ; Phenotypes ; Proacrosin-binding protein ; Reproductive system ; Sperm ; Uterus
  • É parte de: Journal of Reproduction and Development, 2019, Vol.65(2), pp.97-102
  • Notas: K Nagashima and T Usui contributed eqally to this work.
  • Descrição: Gene-knockout mice lacking ACRBP, a proacrosin-binding protein localized in the acrosome of sperm, have been shown to exhibit male subfertility, owing to abnormal formation of the acrosome. In this study, to elucidate the mechanism contributing to the subfertility phenotype, we examined the behavior of ACRBP-deficient mouse sperm in the female reproductive tract. When sperm that had migrated into the uterus and oviduct after mating were counted, the number of ACRBP-deficient sperm was noticeably smaller in the oviduct of mice post mating. However, ACRBP-deficient sperm recovered from the oviduct possessed morphologically normal head shape and retained normal motility. Importantly, ACRBP-deficient sperm displayed a marked reduction in the ability to successfully gain access to unfertilized oocytes. These data suggest that male subfertility of ACRBP-deficient mice may be attributed to incompleteness of the acrosome reaction rather than impairment in sperm migration from the uterus to the oviduct.
  • Editor: Tokyo: THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT
  • Idioma: Inglês;Japonês
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.