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Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: a review

Macone, Alberto ; Fontana, Mario ; Barba, Marco ; Botta, Bruno ; Nardini, Mirella ; Ghirga, Francesca ; Calcaterra, Andrea ; Pecci, Laura ; Matarese, Rosa Marina

International Journal of Molecular Sciences, 2011-05, Vol.12 (5), p.3072-3084 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: a review
Autor: Macone, Alberto ; Fontana, Mario ; Barba, Marco ; Botta, Bruno ; Nardini, Mirella ; Ghirga, Francesca ; Calcaterra, Andrea ; Pecci, Laura ; Matarese, Rosa Marina
Assuntos: aminoethylcysteine ketimine decarboxylated dimer ; Free Radical Scavengers - chemistry ; Free Radical Scavengers - metabolism ; Free Radical Scavengers - pharmacology ; Morpholines - chemistry ; Morpholines - metabolism ; Morpholines - pharmacology ; reactive nitrogen species ; Reactive Nitrogen Species - chemistry ; reactive oxygen species ; Reactive Oxygen Species - chemistry ; Review ; Sulfur - chemistry ; sulfur-containing antioxidants
É parte de: International Journal of Molecular Sciences, 2011-05, Vol.12 (5), p.3072-3084
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Aminoethylcysteine ketimine decarboxylated dimer is a natural sulfur-containing compound detected in human plasma and urine, in mammalian brain and in many common edible vegetables. Over the past decade many studies have been undertaken to identify its metabolic role. Attention has been focused on its antioxidant properties and on its reactivity against oxygen and nitrogen reactive species. These properties have been studied in different model systems starting from plasma lipoproteins to specific cellular lines. All these studies report that aminoethylcysteine ketimine decarboxylated dimer is able to interact both with reactive oxygen and nitrogen species (hydrogen peroxide, superoxide anion, hydroxyl radical, peroxynitrite and its derivatives). Its antioxidant activity is similar to that of Vitamin E while higher than other hydrophilic antioxidants, such as trolox and N-acetylcysteine.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: a review

Macone, Alberto ; Fontana, Mario ; Barba, Marco ; Botta, Bruno ; Nardini, Mirella ; Ghirga, Francesca ; Calcaterra, Andrea ; Pecci, Laura ; Matarese, Rosa Marina

Switzerland: MDPI AG

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