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Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways

De Craene, Johan-Owen ; Bertazzi, Dimitri L ; Bär, Séverine ; Friant, Sylvie

International journal of molecular sciences, 2017-03, Vol.18 (3), p.634-634 [Periódico revisado por pares]

Switzerland: MDPI

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Título:
Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways
Autor: De Craene, Johan-Owen ; Bertazzi, Dimitri L ; Bär, Séverine ; Friant, Sylvie
Assuntos: Actins - metabolism ; Animals ; Autophagy ; Biological Transport ; Biotechnology ; Cell Membrane - metabolism ; Cellular Biology ; Endocytosis ; Endosomes - metabolism ; Humans ; kinase ; Life Sciences ; Lipid Metabolism ; lipids ; Lysosomes - metabolism ; membrane trafficking ; Metabolic Networks and Pathways ; phosphatase ; Phosphatidylinositol 4,5-Diphosphate - metabolism ; Phosphatidylinositol Phosphates - metabolism ; Phosphatidylinositols - metabolism ; phosphoinositides ; Phospholipids - metabolism ; Review ; Signal Transduction ; Sterols - metabolism ; Subcellular Processes ; vesicles
É parte de: International journal of molecular sciences, 2017-03, Vol.18 (3), p.634-634
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Present address: EA 2106, Biomolécules et Biotechnologies Végétales, Université François Rabelais de Tours, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France.
Descrição: Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids between the different compartments of eukaryotic cells. They act by recruiting and/or activating effector proteins and thus are involved in regulating various cellular functions, such as vesicular budding, membrane fusion and cytoskeleton dynamics. Although detected in small concentrations in membranes, their role is essential to cell function, since imbalance in their concentrations is a hallmark of many cancers. Their synthesis involves phosphorylating/dephosphorylating positions D3, D4 and/or D5 of their inositol ring by specific lipid kinases and phosphatases. This process is tightly regulated and specific to the different intracellular membranes. Most enzymes involved in phosphoinositide synthesis are conserved between yeast and human, and their loss of function leads to severe diseases (cancer, myopathy, neuropathy and ciliopathy).
Editor: Switzerland: MDPI
Idioma: Inglês

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Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways

De Craene, Johan-Owen ; Bertazzi, Dimitri L ; Bär, Séverine ; Friant, Sylvie

Switzerland: MDPI

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