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Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Translocation : An Emerging Entity Analyzed in a Series of 41 Cases

Hanna, John ; Ko, Jennifer S ; Billings, Steven D ; Boivin, Felix ; Beaudoux, Olivia ; Pissaloux, Daniel ; Tirode, Franck ; Laga, Alvaro ; Fletcher, Christopher D M ; de la Fouchardiere, Arnaud

The American journal of surgical pathology, 2022-11, Vol.46 (11), p.1457-1466 [Periódico revisado por pares]

United States

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Título:
Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Translocation : An Emerging Entity Analyzed in a Series of 41 Cases
Autor: Hanna, John ; Ko, Jennifer S ; Billings, Steven D ; Boivin, Felix ; Beaudoux, Olivia ; Pissaloux, Daniel ; Tirode, Franck ; Laga, Alvaro ; Fletcher, Christopher D M ; de la Fouchardiere, Arnaud
Assuntos: Humans ; Melanoma - genetics ; Melanoma - pathology ; Sarcoma, Clear Cell - pathology ; Skin Neoplasms - genetics ; Skin Neoplasms - pathology ; Transcription Factors - genetics ; Translocation, Genetic ; Tripartite Motif Proteins - genetics ; Ubiquitin-Protein Ligases - genetics
É parte de: The American journal of surgical pathology, 2022-11, Vol.46 (11), p.1457-1466
Descrição: Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMTCT) is a recently described dermally based neoplasm with melanocytic differentiation. It can easily be confused with clear cell sarcoma and metastatic melanoma. Our understanding of this lesion, including its potential for aggressive disease, has been limited by the small number of previously reported cases (13) and the limited clinical follow-up data. Here, we report a series of 41 CMTCT confirmed by molecular studies. We find that the lesion shows highly uniform and reproducible morphologic, immunohistochemical, and genetic features across a wide variety of anatomic locations and age groups. Among 22 cases with follow-up, 1 local recurrence and 1 nodal metastasis were identified. Our data support the classification of CMTCT as a unique nosologic entity and emphasize the importance of distinguishing this entity from its histologic mimics, especially clear cell sarcoma and metastatic melanoma, to guide therapy and establish accurate prognostic expectations.
Editor: United States
Idioma: Inglês

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Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Translocation : An Emerging Entity Analyzed in a Series of 41 Cases

Hanna, John ; Ko, Jennifer S ; Billings, Steven D ; Boivin, Felix ; Beaudoux, Olivia ; Pissaloux, Daniel ; Tirode, Franck ; Laga, Alvaro ; Fletcher, Christopher D M ; de la Fouchardiere, Arnaud

United States

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