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Involvement of class A calcium channels in the KCl induced Ca2+ influx in hippocampal synaptosomes

MALVA, J. O ; AMBROSIO, A. F ; CARVALHO, A. P ; DUARTE, C. B ; CARVALHO, C. M

Brain research, 1995-10, Vol.696 (1-2), p.242-245 [Periódico revisado por pares]

London: Elsevier

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Título:
Involvement of class A calcium channels in the KCl induced Ca2+ influx in hippocampal synaptosomes
Autor: MALVA, J. O ; AMBROSIO, A. F ; CARVALHO, A. P ; DUARTE, C. B ; CARVALHO, C. M
Assuntos: Animals ; Biological and medical sciences ; Calcium - metabolism ; Calcium Channel Blockers - pharmacology ; Calcium Channels - drug effects ; Calcium Channels - metabolism ; Central nervous system ; Electrophysiology ; Fundamental and applied biological sciences. Psychology ; Hippocampus - drug effects ; Hippocampus - metabolism ; In Vitro Techniques ; Ion Channel Gating - drug effects ; Ion Channel Gating - physiology ; Male ; omega-Agatoxin IVA ; omega-Conotoxin GVIA ; omega-Conotoxins ; Peptides - pharmacology ; Potassium Chloride - pharmacology ; Rats ; Rats, Wistar ; Spider Venoms - pharmacology ; Synaptosomes - drug effects ; Synaptosomes - metabolism ; Vertebrates: nervous system and sense organs
É parte de: Brain research, 1995-10, Vol.696 (1-2), p.242-245
Descrição: Using Ca2+ channel toxins, we determined the types of voltage-sensitive calcium channels activated by two levels of KCl depolarization in hippocampal synaptosomes. The increase in the intracellular Ca2+ concentration ([Ca2+]i) induced by 30 mM KCl was equally sensitive to either omega-agatoxin IVA (omega-Aga IVA) or to omega-conotoxin MVIIC (omega-CgTx MVIIC), and the inhibition produced by these two peptides was not additive. The present results indicate that omega-Aga IVA and omega-CgTx MVIIC do not distinguish between two different VSCC in hippocampal synaptosomes and that they both inhibit a channel with the alpha 1A subunit which is present in the rat hippocampus.
Editor: London: Elsevier
Idioma: Inglês

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Involvement of class A calcium channels in the KCl induced Ca2+ influx in hippocampal synaptosomes

MALVA, J. O ; AMBROSIO, A. F ; CARVALHO, A. P ; DUARTE, C. B ; CARVALHO, C. M

London: Elsevier

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