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Aberrant Brain Functional Connectivity Dynamic Responses to the Valsalva Maneuver in Heart Failure

Song, Xiaopeng ; Roy, Bhaswati ; Lai, Milena ; Sahib, Ashish ; Fonarow, Gregg C ; Woo, Mary A ; Kumar, Rajesh

Journal of Cardiac Failure, 2019-09, Vol.25 (9), p.757-766

eScholarship, University of California

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Título:
Aberrant Brain Functional Connectivity Dynamic Responses to the Valsalva Maneuver in Heart Failure
Autor: Song, Xiaopeng ; Roy, Bhaswati ; Lai, Milena ; Sahib, Ashish ; Fonarow, Gregg C ; Woo, Mary A ; Kumar, Rajesh
Assuntos: 2.1 Biological and endogenous factors ; Aetiology ; Autonomic Nervous System ; Biomedical and Clinical Sciences ; Brain Disorders ; Cardiorespiratory Medicine and Haematology ; Cardiovascular ; Cardiovascular Medicine and Haematology ; Cardiovascular System & Hematology ; Cerebellum ; Cerebral Cortex ; Clinical Research ; Clinical Sciences ; Connectome ; Correlation of Data ; Female ; functional connectivity ; Functional magnetic resonance imaging ; Heart Disease ; Heart Failure ; Humans ; insula ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural Pathways ; Neurosciences ; Nursing ; Valsalva Maneuver
É parte de: Journal of Cardiac Failure, 2019-09, Vol.25 (9), p.757-766
Notas: 757 - 766
Journal of Cardiac Failure, vol 25, iss 9
Descrição: BACKGROUND:Patients with heart failure (HF) show abnormal autonomic activities, which may stem from altered functional connectivity (FC) between different brain sites. METHODS AND RESULTS:We evaluate insular and cerebellar FC with other brain areas, before, during, and after the Valsalva challenge, with functional magnetic resonance imaging in 35 HF and 35 control subjects. Significant insular FC emerged with striatum, thalamus, and anterior cingulate. While left and right cerebellar cortices showed significant FC with each other constituting the cerebellum network, the insula and cerebellum networks showed significant negative FC with each other at baseline, challenge, and recovery phases. The challenge induced increased FC within the insula and the cerebellum networks in both HF and controls. However, patients with HF showed more increased insular network FC, but less enhanced cerebellar FC. During the recovery phase, the negative FC between the insular network and cerebellum enhanced significantly in controls, but not in HF. Lower left ventricle ejection fraction was correlated with lower insula network FC, and impaired negative FC between cerebellum and the insula network in HF. CONCLUSIONS:Increased insular FC in patients with HF might contribute to exaggerated sympathetic tone. While impaired cerebellar FC and diminished negative interactions between cerebellum and insular systems may indicate impaired parasympathetic functions in HF.
Editor: eScholarship, University of California
Idioma: Inglês

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Aberrant Brain Functional Connectivity Dynamic Responses to the Valsalva Maneuver in Heart Failure

Song, Xiaopeng ; Roy, Bhaswati ; Lai, Milena ; Sahib, Ashish ; Fonarow, Gregg C ; Woo, Mary A ; Kumar, Rajesh

eScholarship, University of California

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