Idioma:

Prenatal fever and autism risk

Hornig, M ; Bresnahan, M A ; Che, X ; Schultz, A F ; Ukaigwe, J E ; Eddy, M L ; Hirtz, D ; Gunnes, N ; Lie, K K ; Magnus, P ; Mjaaland, S ; Reichborn-Kjennerud, T ; Schjølberg, S ; Øyen, A-S ; Levin, B ; Susser, E S ; Stoltenberg, C ; Lipkin, W I

Molecular psychiatry, 2018-03, Vol.23 (3), p.759-766 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Prenatal fever and autism risk
Autor: Hornig, M ; Bresnahan, M A ; Che, X ; Schultz, A F ; Ukaigwe, J E ; Eddy, M L ; Hirtz, D ; Gunnes, N ; Lie, K K ; Magnus, P ; Mjaaland, S ; Reichborn-Kjennerud, T ; Schjølberg, S ; Øyen, A-S ; Levin, B ; Susser, E S ; Stoltenberg, C ; Lipkin, W I
Assuntos: Adult ; Autism ; Autism Spectrum Disorder - etiology ; Autistic Disorder - etiology ; Complications and side effects ; Development and progression ; Exposure ; Female ; Fever ; Fever - complications ; Genetic Linkage ; Gestation ; Gestational Age ; Health aspects ; Health risk assessment ; Health risks ; Humans ; Immune response ; Immunity, Innate - immunology ; Infant ; Infant, Newborn ; Infants ; Infection - complications ; Infections ; Innate immunity ; Male ; Maternal Exposure ; Mothers ; Norway ; Odds Ratio ; Offspring ; Original ; Pathogenesis ; Pervasive developmental disorders ; Pregnancy ; Pregnancy Trimester, Second - physiology ; Pregnant women ; Prenatal Exposure Delayed Effects ; Prenatal influences ; Prospective Studies ; Registries ; Risk ; Risk Factors ; Surveys and Questionnaires
É parte de: Molecular psychiatry, 2018-03, Vol.23 (3), p.759-766
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Some studies suggest that prenatal infection increases risk of autism spectrum disorders (ASDs). This study was undertaken in a prospective cohort in Norway to examine whether we could find evidence to support an association of the prenatal occurrence of fever, a common manifestation of infection, with ASD risk. Prospective questionnaires provided maternal exposure data; case status was established from clinical assessments and registry linkages. In a large, prospectively ascertained cohort of pregnant mothers and their offspring, we examined infants born ⩾32 weeks for associations between fever exposure in each trimester and ASD risk using logistic regression. Maternal exposure to second-trimester fever was associated with increased ASD risk, adjusting for presence of fever in other trimesters and confounders (adjusted odds ratio (aOR), 1.40; 95% confidence interval, 1.09-1.79), with a similar, but nonsignificant, point estimate in the first trimester. Risk increased markedly with exposure to three or more fever episodes after 12 weeks' gestation (aOR, 3.12; 1.28-7.63). ASD risk appears to increase with maternal fever, particularly in the second trimester. Risk magnified dose dependently with exposure to multiple fevers after 12 weeks' gestation. Our findings support a role for gestational maternal infection and innate immune responses to infection in the pathogenesis of at least some cases of ASD.
Editor: England: Nature Publishing Group
Idioma: Inglês;Norueguês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Prenatal fever and autism risk

Hornig, M ; Bresnahan, M A ; Che, X ; Schultz, A F ; Ukaigwe, J E ; Eddy, M L ; Hirtz, D ; Gunnes, N ; Lie, K K ; Magnus, P ; Mjaaland, S ; Reichborn-Kjennerud, T ; Schjølberg, S ; Øyen, A-S ; Levin, B ; Susser, E S ; Stoltenberg, C ; Lipkin, W I

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.