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Use of intravascular ultrasound to measure local compliance of the pediatric pulmonary artery: In vitro studies

Weinberg, Craig E. ; Hertzberg, Jean R. ; Shandas, Robin

Journal of the American Society of Echocardiography, 2002-12, Vol.15 (12), p.1507-1514 [Periódico revisado por pares]

United States: Mosby, Inc

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  • Título:
    Use of intravascular ultrasound to measure local compliance of the pediatric pulmonary artery: In vitro studies
  • Autor: Weinberg, Craig E. ; Hertzberg, Jean R. ; Shandas, Robin
  • Assuntos: Child ; Compliance ; Humans ; Hypertension, Pulmonary - diagnostic imaging ; Hypertension, Pulmonary - physiopathology ; In Vitro Techniques ; Lung - blood supply ; Lung - diagnostic imaging ; Models, Cardiovascular ; Pulmonary Artery - diagnostic imaging ; Pulmonary Artery - physiology ; Ultrasonography, Interventional
  • É parte de: Journal of the American Society of Echocardiography, 2002-12, Vol.15 (12), p.1507-1514
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: Background: The accurate measurement of local pulmonary artery compliance in pediatric pulmonary hypertension is an important step toward further understanding the biomechanical and hemodynamic aspects of the disease. The emergence of intravascular ultrasound (IVUS) imaging techniques promises the ability to make such measurements clinically. However, the use of IVUS for compliance measurements has not been validated. Furthermore, confusion exists regarding the most appropriate method to measure compliance. Methods: This study validated IVUS measurements against a laser micrometer standard for 4 elastic tubes of varying compliance. Two methods of quantifying local compliance were explored: The pressure-strain modulus (Ep),(Ep(g/cm2) = ΔP × Rd/ΔR (Where ΔP is pulse pressure, Rd is diastolic radius, and ΔR is systolic minus diastolic radii) and the dynamic compliance (Cdyn),(Cdyn(%/100 mm Hg) = [ΔD/(ΔP × Dd)] × 104 Where ΔD is systolic minus diastolic diameters and Dd is diastolic diameter. Results: IVUS diameter measurements agreed well with laser micrometer data although slight overestimation (mean = 3.67% ± 2.78%) was present. Mean values of Ep ranged from 353.3 g/cm2 to 2676.0 g/cm2; mean Cdyn values ranged from 5.7% diametric change/100 mm Hg to 39.5% diametric change/100 mm Hg for all tube models. Although mean values of Ep and Cdyn could be distinguished among the various tubes, the extremely large measurement uncertainty for Ep precluded statistical differentiation. The uncertainty in Ep increased inversely with the diametric change, indicating a potential limitation of Ep associated with stiffening arteries. Conclusions: We conclude that Cdyn is a more robust mean of quantifying pediatric pulmonary artery compliance, especially as arteries stiffen with chronic pulmonary hypertension. (J Am Soc Echocardiogr 2002;15:1507-14.)
  • Editor: United States: Mosby, Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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