Idioma:

The essential elements of Alzheimer’s disease

Lei, Peng ; Ayton, Scott ; Bush, Ashley I.

The Journal of biological chemistry, 2021-01, Vol.296, p.100105-100105, Article 100105 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por

Título:
The essential elements of Alzheimer’s disease
Autor: Lei, Peng ; Ayton, Scott ; Bush, Ashley I.
Assuntos: Alzheimer’s disease ; clioquinol ; copper ; ferroptosis ; iron ; JBC Reviews ; PBT2 ; selenium ; zinc
É parte de: The Journal of biological chemistry, 2021-01, Vol.296, p.100105-100105, Article 100105
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Treatments for Alzheimer’s disease (AD) directed against the prominent amyloid plaque neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are several other neurochemical abnormalities that occur in the AD brain that warrant renewed emphasis as potential therapeutic targets for this disease. Among those are the elementomic signatures of iron, copper, zinc, and selenium. Here, we review these essential elements of AD for their broad potential to contribute to Alzheimer’s pathophysiology, and we also highlight more recent attempts to translate these findings into therapeutics. A reinspection of large bodies of discovery in the AD field, such as this, may inspire new thinking about pathogenesis and therapeutic targets.
Editor: United States: Elsevier Inc
Idioma: Inglês

Links

Voltar para lista de resultados