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Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

Duda, John E. ; Giasson, Benoit I. ; Mabon, Meghann E. ; Lee, Virginia M.-Y. ; Trojanowski, John Q.

Annals of neurology, 2002-08, Vol.52 (2), p.205-210 [Periódico revisado por pares]

New York: Wiley Subscription Services, Inc., A Wiley Company

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Título:
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
Autor: Duda, John E. ; Giasson, Benoit I. ; Mabon, Meghann E. ; Lee, Virginia M.-Y. ; Trojanowski, John Q.
Assuntos: alpha-Synuclein ; Antibodies, Monoclonal ; Biological and medical sciences ; Corpus Striatum - metabolism ; Corpus Striatum - pathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Humans ; Lewy Body Disease - metabolism ; Lewy Body Disease - pathology ; Medical sciences ; Molecular Weight ; Nerve Tissue Proteins - chemistry ; Nerve Tissue Proteins - immunology ; Nerve Tissue Proteins - metabolism ; Neurology ; Nitrates - metabolism ; Peptide Fragments - metabolism ; Synucleins
É parte de: Annals of neurology, 2002-08, Vol.52 (2), p.205-210
Notas: National Institutes on Aging - No. AG 09215; No. AG 10124; No. AG 00255
ArticleID:ANA10279
Alzheimer's Association - No. Pioneer Award
istex:2D18218C5EA4866EA77441526403A3924A10F1A6
ark:/67375/WNG-00Z4L822-C
National Parkinson's Foundation
Canadian Institutes of Health Research
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Intracytoplasmic inclusions composed of α‐synuclein (α‐syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered α‐syn, we uncovered an unprecedented and extensive burden of α‐syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these α‐syn aggregates may contribute to the parkinsonism seen in these disorders.
Editor: New York: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

Duda, John E. ; Giasson, Benoit I. ; Mabon, Meghann E. ; Lee, Virginia M.-Y. ; Trojanowski, John Q.

New York: Wiley Subscription Services, Inc., A Wiley Company

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