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Varicella vaccine (VARIVAX) in healthy children and adolescents : results from clinical trials, 1987 to 1989

JO WHITE, C ; KUTER, B. J ; HILDEBRAND, C. S ; ISGANITIS, K. L ; MATTHEWS, H ; MILLER, W. J ; PROVOST, P. J ; ELLIS, R. W ; GERETY, R. J ; CALANDRA, G. B

Pediatrics (Evanston), 1991-05, Vol.87 (5), p.604-610 [Periódico revisado por pares]

Elk Grove Village, IL: American Academy of Pediatrics

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Título:
Varicella vaccine (VARIVAX) in healthy children and adolescents : results from clinical trials, 1987 to 1989
Autor: JO WHITE, C ; KUTER, B. J ; HILDEBRAND, C. S ; ISGANITIS, K. L ; MATTHEWS, H ; MILLER, W. J ; PROVOST, P. J ; ELLIS, R. W ; GERETY, R. J ; CALANDRA, G. B
Assuntos: Adolescent ; Antibodies, Viral - blood ; Biological and medical sciences ; Chickenpox ; Chickenpox - prevention & control ; Chickenpox Vaccine ; Child ; Child, Preschool ; Children ; Clinical Trials as Topic ; Female ; General aspects ; Herpesvirus 3, Human - immunology ; Humans ; Infant ; Infectious diseases ; Male ; Medical sciences ; Prevention ; Statistics ; Vaccination ; Vaccination of children ; Vaccines ; Viral Vaccines - administration & dosage ; Viral Vaccines - adverse effects ; Viral Vaccines - immunology
É parte de: Pediatrics (Evanston), 1991-05, Vol.87 (5), p.604-610
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: A total of 3303 healthy children and adolescents, aged 12 months to 17 years, were vaccinated with one of five production lots of a live attenuated varicella vaccine (VARIVAX) containing 1000 to 1625 plaque-forming units per dose. The vaccine was generally well tolerated. Ninety-six percent (2381/2475) of vaccinees responded to vaccination by producing antibody as measured by a glycoprotein-based enzyme-linked immunosorbent assay; 99% (569/576) of those tested maintained antibody at 1 year following vaccination. The incidence of varicella following household exposure in vaccinees was approximately 12%; household contact historically results in 87% infection. Nearly all of the vaccinees who had varicella after vaccination had a clinically modified disease.
Editor: Elk Grove Village, IL: American Academy of Pediatrics
Idioma: Inglês

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Varicella vaccine (VARIVAX) in healthy children and adolescents : results from clinical trials, 1987 to 1989

JO WHITE, C ; KUTER, B. J ; HILDEBRAND, C. S ; ISGANITIS, K. L ; MATTHEWS, H ; MILLER, W. J ; PROVOST, P. J ; ELLIS, R. W ; GERETY, R. J ; CALANDRA, G. B

Elk Grove Village, IL: American Academy of Pediatrics

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