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Adult Outcomes of Youth Irritability: A 20-Year Prospective Community-Based Study

Stringaris, Argyris ; Cohen, Patricia ; Pine, Daniel S ; Leibenluft, Ellen

The American journal of psychiatry, 2009-09, Vol.166 (9), p.1048-1054 [Periódico revisado por pares]

Arlington, VA: American Psychiatric Association

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Título:
Adult Outcomes of Youth Irritability: A 20-Year Prospective Community-Based Study
Autor: Stringaris, Argyris ; Cohen, Patricia ; Pine, Daniel S ; Leibenluft, Ellen
Assuntos: Adolescent ; Adult ; Anxiety Disorders - diagnosis ; Anxiety Disorders - epidemiology ; Behavior ; Biological and medical sciences ; Bipolar Disorder - diagnosis ; Bipolar Disorder - epidemiology ; Child & adolescent psychiatry ; Clinical outcomes ; Cross-Sectional Studies ; Data Collection - statistics & numerical data ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - epidemiology ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Follow-Up Studies ; Humans ; Irritable Mood ; Longitudinal Studies ; Male ; Medical sciences ; Mental depression ; Mental disorders ; New York - epidemiology ; Parents - psychology ; Probability ; Prognosis ; Prospective Studies ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Risk Factors ; Studies ; Surveys and Questionnaires ; Treatment Outcome
É parte de: The American journal of psychiatry, 2009-09, Vol.166 (9), p.1048-1054
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: Objective: Irritability is a widely occurring DSM-IV symptom in youths. However, little is known about the relationship between irritability in early life and its outcomes in mid-adulthood. This study examines the extent to which youth irritability is related to adult psychiatric outcomes by testing the hypothesis that it predicts depressive and generalized anxiety disorders. Method: The authors conducted a longitudinal community-based study of 631 participants whose parents were interviewed when participants were in early adolescence (mean age=13.8 years [SD=2.6]) and who were themselves interviewed 20 years later (mean age=33.2 years [SD=2.9]). Parent-reported irritability in adolescence was used to predict self-reported psychopathology, assessed by standardized diagnostic interview at 20-year follow-up. Results: Cross-sectionally, irritability in adolescence was widely associated with other psychiatric disorders. After adjustment for baseline emotional and behavioral disorders, irritability in adolescence predicted major depressive disorder (odds ratio=1.33, 95% confidence interval [CI]=1.00-1.78]), generalized anxiety disorder (odds ratio=1.72, 95% CI=1.04-2.87), and dysthymia (odds ratio=1.81, 95% CI=1.06-3.12) at 20-year follow-up. Youth irritability did not predict bipolar disorder or axis II disorders at follow-up. Conclusions: Youth irritability as reported by parents is a specific predictor of self-reported depressive and anxiety disorders 20 years later. The role of irritability in developmental psychiatry, and in the pathophysiology of mood and anxiety disorders specifically, should receive further study.
Editor: Arlington, VA: American Psychiatric Association
Idioma: Inglês

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Adult Outcomes of Youth Irritability: A 20-Year Prospective Community-Based Study

Stringaris, Argyris ; Cohen, Patricia ; Pine, Daniel S ; Leibenluft, Ellen

Arlington, VA: American Psychiatric Association

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