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Current progression in application of extracellular vesicles in central nervous system diseases

Zhang, Xiang-Min ; Huang, Jie ; Ni, Xiao-Ying ; Zhu, Hui-Ru ; Huang, Zhong-Xin ; Ding, Shuang ; Yang, Xin-Yi ; Tan, Yan-Di ; Chen, Jian-Fu ; Cai, Jin-Hua

European journal of medical research, 2024-01, Vol.29 (1), p.15-15, Article 15 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Current progression in application of extracellular vesicles in central nervous system diseases
Autor: Zhang, Xiang-Min ; Huang, Jie ; Ni, Xiao-Ying ; Zhu, Hui-Ru ; Huang, Zhong-Xin ; Ding, Shuang ; Yang, Xin-Yi ; Tan, Yan-Di ; Chen, Jian-Fu ; Cai, Jin-Hua
Assuntos: Biomarkers ; Biomarkers - metabolism ; Blood-Brain Barrier ; Brain ; Cancer therapies ; Cell division ; Central nervous system ; Central nervous system diseases ; Central Nervous System Diseases - diagnosis ; Central Nervous System Diseases - metabolism ; Central Nervous System Diseases - therapy ; Contrast agents ; Development and progression ; Drug delivery systems ; Drugs ; Extracellular vesicles ; Extracellular Vesicles - metabolism ; Humans ; Ischemia ; Labeling ; Ligands ; Magnetic resonance imaging ; Medical imaging ; Medical research ; Medicine, Experimental ; MicroRNAs ; Molecular therapy ; Nanoparticles ; Nervous system ; Nervous system diseases ; Neurophysiology ; Peptides ; Physiology ; Proteins ; Review ; Tomography ; Toxicity ; Tumors ; Vehicles
É parte de: European journal of medical research, 2024-01, Vol.29 (1), p.15-15, Article 15
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Early diagnosis and pharmacological treatment of central nervous system (CNS) diseases has been a long-standing challenge for clinical research due to the presence of the blood-brain barrier. Specific proteins and RNAs in brain-derived extracellular vesicles (EVs) usually reflect the corresponding state of brain disease, and therefore, EVs can be used as diagnostic biomarkers for CNS diseases. In addition, EVs can be engineered and fused to target cells for delivery of cargo, demonstrating the great potential of EVs as a nanocarrier platform. We review the progress of EVs as markers and drug carriers in the diagnosis and treatment of neurological diseases. The main areas include visual imaging, biomarker diagnosis and drug loading therapy for different types of CNS diseases. It is hoped that increased knowledge of EVs will facilitate their clinical translation in CNS diseases.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Current progression in application of extracellular vesicles in central nervous system diseases

Zhang, Xiang-Min ; Huang, Jie ; Ni, Xiao-Ying ; Zhu, Hui-Ru ; Huang, Zhong-Xin ; Ding, Shuang ; Yang, Xin-Yi ; Tan, Yan-Di ; Chen, Jian-Fu ; Cai, Jin-Hua

England: BioMed Central Ltd

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