Idioma:

A High-Coverage Genome Sequence from an Archaic Denisovan Individual

Meyer, Matthias ; Kircher, Martin ; Gansauge, Marie-Theres ; Li, Heng ; Racimo, Fernando ; Mallick, Swapan ; Schraiber, Joshua G. ; Jay, Flora ; Prüfer, Kay ; de Filippo, Cesare ; Sudmant, Peter H. ; Alkan, Can ; Fu, Qiaomei ; Do, Ron ; Rohland, Nadin ; Tandon, Arti ; Siebauer, Michael ; Green, Richard E. ; Bryc, Katarzyna ; Briggs, Adrian W. ; Stenzel, Udo ; Dabney, Jesse ; Shendure, Jay ; Kitzman, Jacob ; Hammer, Michael F. ; Shunkov, Michael V. ; Derevianko, Anatoli P. ; Patterson, Nick ; Andrés, Aida M. ; Eichler, Evan E. ; Slatkin, Montgomery ; Reich, David ; Kelso, Janet ; Pääbo, Svante

Science (American Association for the Advancement of Science), 2012-10, Vol.338 (6104), p.222-226 [Periódico revisado por pares]

United States: American Association for the Advancement of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
A High-Coverage Genome Sequence from an Archaic Denisovan Individual
Autor: Meyer, Matthias ; Kircher, Martin ; Gansauge, Marie-Theres ; Li, Heng ; Racimo, Fernando ; Mallick, Swapan ; Schraiber, Joshua G. ; Jay, Flora ; Prüfer, Kay ; de Filippo, Cesare ; Sudmant, Peter H. ; Alkan, Can ; Fu, Qiaomei ; Do, Ron ; Rohland, Nadin ; Tandon, Arti ; Siebauer, Michael ; Green, Richard E. ; Bryc, Katarzyna ; Briggs, Adrian W. ; Stenzel, Udo ; Dabney, Jesse ; Shendure, Jay ; Kitzman, Jacob ; Hammer, Michael F. ; Shunkov, Michael V. ; Derevianko, Anatoli P. ; Patterson, Nick ; Andrés, Aida M. ; Eichler, Evan E. ; Slatkin, Montgomery ; Reich, David ; Kelso, Janet ; Pääbo, Svante
Assuntos: Alleles ; Animals ; Base Sequence ; Deoxyribonucleic acid ; DNA ; Fossils ; Gene Flow ; Gene Library ; Gene sequencing ; Genetic diversity ; Genetic mutation ; Genetic Variation ; Genetics ; Genome, Human - genetics ; Genomes ; Genomics ; Heterozygote ; Hominids ; Human ; Human genome ; Humans ; Libraries ; Molecular Sequence Data ; Molecules ; Neanderthals - genetics ; Online ; Population genetics ; Population size ; Populations ; Sequence Analysis, DNA
É parte de: Science (American Association for the Advancement of Science), 2012-10, Vol.338 (6104), p.222-226
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Current address: Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
These authors contributed equally to this work
Descrição: We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of "missing evolution" in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans.
Editor: United States: American Association for the Advancement of Science
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

A High-Coverage Genome Sequence from an Archaic Denisovan Individual

United States: American Association for the Advancement of Science

Buscando em bases de dados remotas. Favor aguardar.