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Hormones of the hypothalamic-pituitary-gonadal (HPG) axis in male depressive disorders – A systematic review and meta-analysis

Fischer, Susanne ; Ehlert, Ulrike ; Amiel Castro, Rita

Frontiers in neuroendocrinology, 2019-10, Vol.55, p.100792-100792, Article 100792 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Hormones of the hypothalamic-pituitary-gonadal (HPG) axis in male depressive disorders – A systematic review and meta-analysis
  • Autor: Fischer, Susanne ; Ehlert, Ulrike ; Amiel Castro, Rita
  • Assuntos: Depression ; Depressive Disorder - metabolism ; Estradiol - metabolism ; Follicle Stimulating Hormone - metabolism ; Follicle-stimulating hormone ; Humans ; Hypothalamo-Hypophyseal System - metabolism ; Luteinising hormone ; Luteinizing Hormone - metabolism ; Male ; Oestradiol ; Testosterone ; Testosterone - metabolism
  • É parte de: Frontiers in neuroendocrinology, 2019-10, Vol.55, p.100792-100792, Article 100792
  • Notas: ObjectType-Article-2
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  • Descrição: •Depressed men had significantly lower testosterone than healthy controls.•No alterations in follicle-stimulating hormone or luteinising hormone were observed.•Sampling tissue and BMI were effect modifiers regarding testosterone. Sexual dysfunctions are common in men with depression. As the hypothalamic-pituitary-gonadal (HPG) axis is a crucial regulator of sexual function, and also affects mood and cognition, the following question arises: Is the HPG axis altered in depressed men when compared to healthy controls? To answer this question, PubMed and PsycINFO were searched. Inclusion criteria for the systematic review and meta-analysis were: (1) case-control study including male patients with a depressive disorder and (2) assessment of follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol, or testosterone. Seventeen studies were identified. Follicle-stimulating hormone and LH did not differ between patients and controls. By contrast, in patients, oestradiol was marginally increased (g = 0.52, 95% CI [−0.01, 1.04]; Z = 1.92, p = .055) and testosterone was significantly decreased (g = −0.45, 95% CI [−0.80, −0.10]; Z = −2.53, p = .012). Depressed men may be characterised by diminished testosterone and potentially elevated oestradiol, which beyond contributing to sexual dysfunction, could impact mood and cognition.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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