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Reproductive toxicity of Campomanesia xanthocarpa (Berg.) in female Wistar rats

Auharek, Sarah Alves ; do Carmo Vieira, Maria ; Cardoso, Claudia Andrea Lima ; Oliveira, Rodrigo Juliano ; Cunha-Laura, Andréa Luiza

Journal of ethnopharmacology, 2013-06, Vol.148 (1), p.341-343 [Periódico revisado por pares]

Ireland: Elsevier Ireland Ltd

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Título:
Reproductive toxicity of Campomanesia xanthocarpa (Berg.) in female Wistar rats
Autor: Auharek, Sarah Alves ; do Carmo Vieira, Maria ; Cardoso, Claudia Andrea Lima ; Oliveira, Rodrigo Juliano ; Cunha-Laura, Andréa Luiza
Assuntos: Animals ; Campomanesia ; Campomanesia xanthocarpa ; euthanasia ; Female ; kidneys ; liver ; Medicinal plants ; Myrtaceae ; placenta ; Plant Extracts - pharmacology ; Pregnancy ; Pregnant rat ; Rats ; Rats, Wistar ; Reproduction - drug effects ; reproductive toxicology ; spleen
É parte de: Journal of ethnopharmacology, 2013-06, Vol.148 (1), p.341-343
Notas: http://dx.doi.org/10.1016/j.jep.2013.04.010
Descrição: There is no evidence in the literature that substantiates the safety of Campomanesia xanthocarpa (Berg.) use during pregnancy. Thirty three female rats were randomly assigned to three groups. One group of animals received the Campomanesia xanthocarpa extract via gavage at a dose of 26.3mg/kg/day from 6 to 15 days of pregnancy (organogenic period, T1) and another group received the same extract throughout the gestational period (from the 1st to the 20th day of pregnancy, T2). Control groups received distilled water. Euthanasia was done on 20th day, when the liver, kidney, spleen ovaries, fetuses and their respective placentas were removed. Implantations, reabsorptions, live and dead fetuses were recorded. Campomanesia xanthocarpa, in these experimental conditions, did not disturb the reproductive function of female rats and did not interrupt the progress of the embryofetal development. Moreover, our results provide further evidence that the Campomanesia xanthocarpa treatment reduces reabsorption sites, increases placenta weight and the number of live fetuses and may therefore have therapeutic applications. [Display omitted]
Editor: Ireland: Elsevier Ireland Ltd
Idioma: Inglês

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Reproductive toxicity of Campomanesia xanthocarpa (Berg.) in female Wistar rats

Auharek, Sarah Alves ; do Carmo Vieira, Maria ; Cardoso, Claudia Andrea Lima ; Oliveira, Rodrigo Juliano ; Cunha-Laura, Andréa Luiza

Ireland: Elsevier Ireland Ltd

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