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From Catheter to Kidney Stone: The Uropathogenic Lifestyle of Proteus mirabilis

Norsworthy, Allison N ; Pearson, Melanie M

Trends in microbiology (Regular ed.), 2017-04, Vol.25 (4), p.304-315 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
From Catheter to Kidney Stone: The Uropathogenic Lifestyle of Proteus mirabilis
Autor: Norsworthy, Allison N ; Pearson, Melanie M
Assuntos: Bacteria ; Bacterial Proteins - metabolism ; Biofilms ; Biofilms - growth & development ; Bladder ; Catheter-Related Infections - microbiology ; Catheter-Related Infections - pathology ; Catheters ; CAUTI ; Clusters ; crystalline biofilms ; fimbriae ; Fimbriae, Bacterial - metabolism ; Humans ; Infections ; Internal Medicine ; Kidney Calculi - microbiology ; Kidney Calculi - pathology ; Kidney stones ; Kidneys ; Medical instruments ; Pili ; polymicrobial infections ; Proteus Infections - microbiology ; Proteus Infections - pathology ; Proteus mirabilis ; Proteus mirabilis - growth & development ; Proteus mirabilis - pathogenicity ; Repressor Proteins - metabolism ; Urease ; Urease - biosynthesis ; Urinary bladder ; Urinary Bladder - microbiology ; urinary stones ; Urinary tract ; Urinary tract diseases ; Urinary Tract Infections - microbiology ; Urinary Tract Infections - pathology ; Virulence ; Virulence factors
É parte de: Trends in microbiology (Regular ed.), 2017-04, Vol.25 (4), p.304-315
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Current address: University of Michigan Medical School, Department of Microbiology and Immunology, 5641 Medical Science Building II, 1150 West Medical Center Dr., Ann Arbor, MI 48109-0620, USA
Descrição: Proteus mirabilis is a model organism for urease-producing uropathogens. These diverse bacteria cause infection stones in the urinary tract and form crystalline biofilms on indwelling urinary catheters, frequently leading to polymicrobial infection. Recent work has elucidated how P. mirabilis causes all of these disease states. Particularly exciting is the discovery that this bacterium forms large clusters in the bladder lumen that are sites for stone formation. These clusters, and other steps of infection, require two virulence factors in particular: urease and MR/P fimbriae. Highlighting the importance of MR/P fimbriae is the cotranscribed regulator, MrpJ, which globally controls virulence. Overall, P. mirabilis exhibits an extraordinary lifestyle, and further probing will answer exciting basic microbiological and clinically relevant questions.
Editor: England: Elsevier Ltd
Idioma: Inglês

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From Catheter to Kidney Stone: The Uropathogenic Lifestyle of Proteus mirabilis

Norsworthy, Allison N ; Pearson, Melanie M

England: Elsevier Ltd

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