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Three-Layer Composite Magnetic Nanoparticle Probes for DNA

Stoeva, Savka I ; Huo, Fengwei ; Lee, Jae-Seung ; Mirkin, Chad A

Journal of the American Chemical Society, 2005-11, Vol.127 (44), p.15362-15363 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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Título:
Three-Layer Composite Magnetic Nanoparticle Probes for DNA
Autor: Stoeva, Savka I ; Huo, Fengwei ; Lee, Jae-Seung ; Mirkin, Chad A
Assuntos: Biological and medical sciences ; Chemistry ; Colloidal state and disperse state ; Disperse state. Micelles ; DNA - analysis ; DNA Probes - chemical synthesis ; Exact sciences and technology ; Ferrous Compounds ; Fundamental and applied biological sciences. Psychology ; General and physical chemistry ; Gold ; Hot Temperature ; Magnetics ; Molecular biophysics ; Nanostructures ; Nucleic Acid Denaturation ; Oligonucleotides ; Physical and chemical studies. Granulometry. Electrokinetic phenomena ; Physico-chemical properties of biomolecules
É parte de: Journal of the American Chemical Society, 2005-11, Vol.127 (44), p.15362-15363
Notas: istex:136F2FA232B2E231885D487AB76249FF51FF4E01
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ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: A method for synthesizing composite nanoparticles with a gold shell, an Fe3O4 inner shell, and a silica core has been developed. The approach utilizes positively charged amino-modified SiO2 particles as templates for the assembly of negatively charged 15 nm superparamagnetic water-soluble Fe3O4 nanoparticles. The SiO2−Fe3O4 particles electrostatically attract 1−3 nm Au nanoparticle seeds that act in a subsequent step as nucleation sites for the formation of a continuous gold shell around the SiO2−Fe3O4 particles upon HAuCl4 reduction. The three-layer magnetic nanoparticles, when functionalized with oligonucleotides, exhibit the surface chemistry, optical properties, and cooperative DNA binding properties of gold nanoparticle probes, but the magnetic properties of the Fe3O4 inner shell.
Editor: Washington, DC: American Chemical Society
Idioma: Inglês

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Three-Layer Composite Magnetic Nanoparticle Probes for DNA

Stoeva, Savka I ; Huo, Fengwei ; Lee, Jae-Seung ; Mirkin, Chad A

Washington, DC: American Chemical Society

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