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The conceptual foundations of innate immunity: Taking stock 30 years later

Pradeu, Thomas ; Thomma, Bart P.H.J. ; Girardin, Stephen E. ; Lemaitre, Bruno

Immunity (Cambridge, Mass.), 2024-04, Vol.57 (4), p.613-631 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    The conceptual foundations of innate immunity: Taking stock 30 years later
  • Autor: Pradeu, Thomas ; Thomma, Bart P.H.J. ; Girardin, Stephen E. ; Lemaitre, Bruno
  • Assuntos: Adaptive Immunity ; Animals ; concepts ; History, Philosophy and Sociology of Sciences ; Humanities and Social Sciences ; Immunity, Innate ; Immunologic Memory ; Immunology ; Innate immunity ; innate memory ; Invertebrates ; Life Sciences ; pattern recognition ; Vertebrates
  • É parte de: Immunity (Cambridge, Mass.), 2024-04, Vol.57 (4), p.613-631
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: While largely neglected over decades during which adaptive immunity captured most of the attention, innate immune mechanisms have now become central to our understanding of immunology. Innate immunity provides the first barrier to infection in vertebrates, and it is the sole mechanism of host defense in invertebrates and plants. Innate immunity also plays a critical role in maintaining homeostasis, shaping the microbiota, and in disease contexts such as cancer, neurodegeneration, metabolic syndromes, and aging. The emergence of the field of innate immunity has led to an expanded view of the immune system, which is no longer restricted to vertebrates and instead concerns all metazoans, plants, and even prokaryotes. The study of innate immunity has given rise to new concepts and language. Here, we review the history and definition of the core concepts of innate immunity, discussing their value and fruitfulness in the long run. Recent studies revealed the existence of common principles of innate immune mechanisms across kingdoms and between the innate and adaptive branches of immunity in vertebrates. Lemaitre et al. discuss some key concepts of innate immunity that have renewed our vision of the immune system.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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