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Cytokines dynamics in a wistar rat model infected with Mycobacterium Tuberculosis strain H37Rv

Singh, Bobby ; Wasita, Brian ; Reviono, Reviono

International journal of mycobacteriology, 2022-07, Vol.11 (3), p.299-302 [Periódico revisado por pares]

India: Wolters Kluwer - Medknow Publications

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  • Título:
    Cytokines dynamics in a wistar rat model infected with Mycobacterium Tuberculosis strain H37Rv
  • Autor: Singh, Bobby ; Wasita, Brian ; Reviono, Reviono
  • Assuntos: Animals ; Cytokines ; experimental animal models ; granuloma ; Health aspects ; immunology ; Interleukin-12 ; Interleukin-17 ; Interleukin-2 ; Interleukin-4 ; Interleukin-6 ; Interleukins ; Latent Tuberculosis ; Male ; Mycobacterium tuberculosis ; pathology ; pulmonary tuberculosis ; Rats ; Rats, Wistar ; Tuberculosis ; Tuberculosis - microbiology ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha
  • É parte de: International journal of mycobacteriology, 2022-07, Vol.11 (3), p.299-302
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Background: The immunology characteristics of the rat model of tuberculosis (TB) infection are still unclear. This study aimed to evaluate the dynamics of pathology and cytokines in a rat model infected with Mycobacterium TB (MTB). Methods: Sixty male Wistar rats were divided into four groups, namely the control group (without MTB infection) and the MTB -induced group (observations at week-3, week-6, and week-12 postinfection). Granuloma formation was analyzed by histology procedure. Analysis of the levels of tumor necrosis factor-a (TNF-α), interleukin-6 (IL-6), IL-17, IL-2, IL-4, and IL-12 was performed using an enzyme-linked immunosorbent assay technique. Results: The number and size of the ganulomas increased proportionally between weeks 6 and 12 postinfection. Several cytokines, namely IL-6, IL-17, IL-2, IL-4, and IL-12 significantly increased in the 6th week compared to the 3rd week after infection (P < 0.05). These cytokines decreased significantly at the 12th week compared to the 6th week (P < 0.05). TNF-α was found to be stable at the third and 6th weeks and then decreased at the twelfth postinfection week. For IL-12, the longer the infection time, the higher the level. Conclusions: It was concluded that there was a typical pattern of TB infection in Wistar rats, namely certain cytokines that peaked at week 6 of infection. Thus, TB infection in rats can be a model for early-phase TB study.
  • Editor: India: Wolters Kluwer - Medknow Publications
  • Idioma: Inglês
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