Idioma:

Mechanochemical coupling in eukaryotic flagella

Omoto, Charlotte K.

Journal of theoretical biology, 1989-03, Vol.137 (2), p.163-169 [Periódico revisado por pares]

Sidcup: Elsevier Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Mechanochemical coupling in eukaryotic flagella
Autor: Omoto, Charlotte K.
Assuntos: Adenosine Triphosphatases - metabolism ; Adenosine Triphosphate - metabolism ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Cytoskeleton - metabolism ; Dyneins - metabolism ; Enzymes and enzyme inhibitors ; Flagella - metabolism ; Flagella - physiology ; Fundamental and applied biological sciences. Psychology ; Hydrolases ; Kinetics ; Models, Biological ; Movement
É parte de: Journal of theoretical biology, 1989-03, Vol.137 (2), p.163-169
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Quantitative analyses of ATP hydrolysis coupled to movement of eukaryotic flagella is important for understanding the relationship between ATP hydrolysis and movement. The difference in ATPase activity between intact motile axonemes (that is the cytoskeletal core of flagella) and homogenized or immotile axonemes has been assumed to be coupled to movement. However, recent findings on rates of steps in the dynein ATPase cycle and the effect of interaction with microtubules on those steps call for reassessment of movement-coupled ATPase. From these studies, it is clear that dynein ATPase activity is not as tightly coupled to interaction with microtubles as myosin ATPase activity is coupled to interaction with actin. The method by which axonemal movement is inhibited will critically affect the interpretation of difference in ATPase activity. If the homogenization or similar methods uncouple dynein, the difference in ATPase activity is not a useful measurement. Greater understanding of the relationship between dynein kinetics and axonemal movement may be obtained by use of conditions and substrates with known effects at specific steps in the dynein mechanochemical cycle and quantitating their effects on movement.
Editor: Sidcup: Elsevier Ltd
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Mechanochemical coupling in eukaryotic flagella

Omoto, Charlotte K.

Sidcup: Elsevier Ltd

Buscando em bases de dados remotas. Favor aguardar.