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Metal Preferences and Metallation

Foster, Andrew W. ; Osman, Deenah ; Robinson, Nigel J.

The Journal of biological chemistry, 2014-10, Vol.289 (41), p.28095-28103 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Metal Preferences and Metallation
Autor: Foster, Andrew W. ; Osman, Deenah ; Robinson, Nigel J.
Assuntos: Bacillus subtilis - chemistry ; Bacillus subtilis - metabolism ; Bacterial Proteins - chemistry ; Bacterial Proteins - metabolism ; Biological Transport ; Clostridium - chemistry ; Clostridium - metabolism ; Cyanobacteria - chemistry ; Cyanobacteria - metabolism ; Escherichia coli - chemistry ; Escherichia coli - metabolism ; Helicobacter pylori - chemistry ; Helicobacter pylori - metabolism ; Iron - chemistry ; Iron - metabolism ; Kinetics ; Magnesium - chemistry ; Magnesium - metabolism ; Manganese - chemistry ; Manganese - metabolism ; Metalloproteins - chemistry ; Metalloproteins - metabolism ; Minireviews ; Models, Molecular ; Thermodynamics ; Zinc - chemistry ; Zinc - metabolism
É parte de: The Journal of biological chemistry, 2014-10, Vol.289 (41), p.28095-28103
Notas: ObjectType-Article-2
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Descrição: The metal binding preferences of most metalloproteins do not match their metal requirements. Thus, metallation of an estimated 30% of metalloenzymes is aided by metal delivery systems, with ∼25% acquiring preassembled metal cofactors. The remaining ∼70% are presumed to compete for metals from buffered metal pools. Metallation is further aided by maintaining the relative concentrations of these pools as an inverse function of the stabilities of the respective metal complexes. For example, magnesium enzymes always prefer to bind zinc, and these metals dominate the metalloenzymes without metal delivery systems. Therefore, the buffered concentration of zinc is held at least a million-fold below magnesium inside most cells.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Metal Preferences and Metallation

Foster, Andrew W. ; Osman, Deenah ; Robinson, Nigel J.

United States: Elsevier Inc

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