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Aloin delivery on buccal mucosa: ex vivo studies and design of a new locoregional dosing system

De Caro, Viviana ; Scaturro, Anna Lisa ; Di Prima, Giulia ; Avellone, Giuseppe ; Sutera, Flavia Maria ; Di Fede, Olga ; Campisi, Giuseppina ; Giannola, Libero Italo

Drug development and industrial pharmacy, 2015-01, Vol.41 (9), p.1541-1547 [Periódico revisado por pares]

England: Informa Healthcare

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Título:
Aloin delivery on buccal mucosa: ex vivo studies and design of a new locoregional dosing system
Autor: De Caro, Viviana ; Scaturro, Anna Lisa ; Di Prima, Giulia ; Avellone, Giuseppe ; Sutera, Flavia Maria ; Di Fede, Olga ; Campisi, Giuseppina ; Giannola, Libero Italo
Assuntos: Acrylic Resins - chemistry ; Adhesiveness ; Aloe - chemistry ; Aloin matrix tablets ; Animals ; barbaloin ; buccal mucosa ; buccal tablets ; Chemistry, Pharmaceutical - methods ; Drug Delivery Systems ; Drug Liberation ; Emodin - administration & dosage ; Emodin - analogs & derivatives ; Emodin - pharmacokinetics ; locoregional drug delivery ; Mouth Mucosa - metabolism ; oro-mucosal delivery ; Permeability ; Polymers - chemistry ; Reproducibility of Results ; Swine ; Tablets
É parte de: Drug development and industrial pharmacy, 2015-01, Vol.41 (9), p.1541-1547
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Context: Chemoprevention of potential malignant disorders or cancerous lesions that affect oral mucosae requires extended duration of treatment. Locoregional delivery of natural products could represent a promising strategy for this purpose. Objective: To investigate the aptitude of aloin to permeate through, or accumulate in, the buccal mucosa and to develop a new prolonged oro-mucosal drug delivery system. Materials and methods: Permeation/accumulation of aloin from Curacao Aloe (containing 50% barbaloin) was evaluated ex vivo, using porcine buccal mucosa as the most useful model to simulate human epithelium. Oro-mucosal matrix tablets were prepared by dispersing aloin (10% w/w) in Eudragit® RS 100 as, biocompatible, low permeable, pH-independent, and non-swelling polymer. The prepared tablets were evaluated for drug-polymer compatibility, weight variation, drug uniformity content, diameter, thickness, hardness, friability, swelling, mucoadhesive strength, and drug release. Results: Aloin has low tendency to cross buccal mucosa, permeation is marginal, and high drug amounts remain entrapped into the epithelium. Matrix tablets characteristics were in agreement with pharmacopoeial requirements. Drug release showed highly reproducible Higuchian profile. Delivery through matrix tablets promoted drug accumulation in the mucosal tissue. Discussion and conclusion: Following application of matrix tablets on porcine buccal mucosa, the amount of discharged drug recovered in the tissue should be sufficient to produce the desired effects, providing therapeutic drug levels directly at the site of action. Aloin-loaded tablets are valid candidates for prevention/treatment of potentially malignant disorders and oral cancer and could potentially lead to clinically relevant drug delivery system as coadjuvant of conventional chemotherapy/radiation therapy.
Editor: England: Informa Healthcare
Idioma: Inglês

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Aloin delivery on buccal mucosa: ex vivo studies and design of a new locoregional dosing system

De Caro, Viviana ; Scaturro, Anna Lisa ; Di Prima, Giulia ; Avellone, Giuseppe ; Sutera, Flavia Maria ; Di Fede, Olga ; Campisi, Giuseppina ; Giannola, Libero Italo

England: Informa Healthcare

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