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Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation

Hermanson, Daniel J ; Gamble-George, Joyonna C ; Marnett, Lawrence J ; Patel, Sachin

Trends in pharmacological sciences (Regular ed.), 2014-07, Vol.35 (7), p.358-367 [Periódico revisado por pares]

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Título:
Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation
Autor: Hermanson, Daniel J ; Gamble-George, Joyonna C ; Marnett, Lawrence J ; Patel, Sachin
Assuntos: Advanced Basic Science ; Animals ; Cannabinoids - metabolism ; Cyclooxygenase 2 - metabolism ; Cyclooxygenase 2 Inhibitors - pharmacology ; Humans ; Signal Transduction - drug effects ; Substrate Specificity
É parte de: Trends in pharmacological sciences (Regular ed.), 2014-07, Vol.35 (7), p.358-367
Descrição: Highlights • Endocannabinoid augmentation may have broad therapeutic implications. • COX-2 is a third endocannabinoid metabolic mechanism. • Substrate-selective COX-2 inhibition increases central endocannabinoid signaling. • Substrate-selective COX-2 inhibition decreases anxiety.
Editor: England: Elsevier Ltd
Idioma: Inglês

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