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Pathophysiology of Erectile Dysfunction

Matsui, Hotaka ; Sopko, Nikolai A ; Hannan, Johanna L ; Bivalacqua, Trinity J

Current drug targets, 2015-05, Vol.16 (5), p.411-419 [Periódico revisado por pares]

United Arab Emirates: Bentham Science Publishers Ltd

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Título:
Pathophysiology of Erectile Dysfunction
Autor: Matsui, Hotaka ; Sopko, Nikolai A ; Hannan, Johanna L ; Bivalacqua, Trinity J
Assuntos: Animals ; Cardiovascular Diseases - complications ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 2 - complications ; Erectile Dysfunction - epidemiology ; Erectile Dysfunction - etiology ; Erectile Dysfunction - metabolism ; Erectile Dysfunction - pathology ; Humans ; Male ; Risk Factors ; Signal Transduction
É parte de: Current drug targets, 2015-05, Vol.16 (5), p.411-419
Descrição: Erectile dysfunction (ED) is a major health problem as the population ages. Basic science research for the last two decades has expanded the knowledge on ED and identified several key molecular changes associated with the pathogenesis of ED, including nitric oxide (NO) / cyclic guanosine monophosphate (cGMP) / protein kinase G (PKG) pathway, RhoA/Rho-associated protein kinase (ROCK) signaling pathway, reactive oxygen species (ROS), renin-angiotensin system (RAS) and tumor necrosis factor-alpha (TNF-α). The causes of ED are classified into aging, vasculogenic, neurogenic, endocrinological, drug-induced and psychogenic. ED is often associated with systemic diseases, such as diabetes and cardiovascular diseases. In this review, we will review the molecular mechanisms of ED and known mechanisms behind ED associated with systemic diseases.
Editor: United Arab Emirates: Bentham Science Publishers Ltd
Idioma: Inglês

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Pathophysiology of Erectile Dysfunction

Matsui, Hotaka ; Sopko, Nikolai A ; Hannan, Johanna L ; Bivalacqua, Trinity J

United Arab Emirates: Bentham Science Publishers Ltd

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